Spectroscopic investigation of the effects of advanced glycation end products on fibroblast migration: implications for diabetic wound healing (Invited Paper)

The formation of advanced glycation end products (AGEs) has been implicated in diabetic pathogenesis. Since some AGEs are fluorescent, fluorescent AGEs may be used as long-term glycemic biomarkers to monitor the extent of diabetic pathogenesis. In the case of wound healing, AGEs may hinder migration and contribute to apoptosis of fibroblasts, thereby disrupt wound healing. In this study, we study the relationship between fluorescence of glycated matrix from different monosaccharides and the migratory behavior of fibroblasts. Our results will provide insights on the use of fluorescent AGEs to monitor wound healing and improvement in monitoring diabetic pathogenesis.