The Moscone Center
San Francisco, California, United States
2 - 7 February 2019
Conference 10873
Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis
Tuesday - Wednesday 5 - 6 February 2019
Important
Dates
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Abstract Due:
25 July 2018

Author Notification:
1 October 2018

Manuscript Due Date:
11 January 2019

Conference
Cosponsors
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Conference
Committee
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Conference Chairs
Program Committee
Program Committee continued...
Tuesday 5 February Show All Abstracts
Session REM:
Opening Remarks
Tuesday 5 February 2019
8:00 AM - 8:10 AM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
Robert R. Alfano, The City College of New York (United States)
Session 1:
Optical Bioassay Platforms I
Tuesday 5 February 2019
8:10 AM - 10:00 AM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
Nicusor V. Iftimia, Physical Sciences Inc. (United States)
Chip-based Raman spectroscopy for microbial sensing (Invited Paper)
Paper 10873-1
Time: 8:10 AM - 8:40 AM
Author(s): Jürgen Popp, Leibniz-Institut für Photonische Technologien e.V. (Germany)
Show Abstract
Cytopathology diagnosis by multiplexed plasmonic biomarkers
Paper 10873-2
Time: 8:40 AM - 9:00 AM
Author(s): Sergiy Patskovsky, Mengjiao Qi, Cécile Darviot, Lu Wang, Audrey Nsamela, Daniel Tomasso, Michel Meunier, Ecole Polytechnique de Montréal (Canada)
Show Abstract
Oxygenation based perfusion assessment of diabetic foot ulcers using a breath hold paradigm
Paper 10873-3
Time: 9:00 AM - 9:20 AM
Author(s): Kevin Leiva, Jagadeesh Mahadevan, Priscilla Lozano, Kacie Kaile, Richard Schutzman, Edwin A. Robledo, Dinesh Khandavilli, Florida International Univ. (United States); Sivakumar Narayanan, Varalakshmi Muthukrishnan, Mohan Viswanathan, Dr. Mohan's Diabetes Specialities Ctr. (India); Wensong Wu, Anuradha Godavarty, Florida International Univ. (United States)
Show Abstract
Semi-automated machine learning approach to segment and register tissue oxygenation maps onto clinical images of wounds
Paper 10873-4
Time: 9:20 AM - 9:40 AM
Author(s): Edwin A. Robledo, Richard Schutzman, Florida International Univ. (United States); Ruogu Fang, Univ. of Florida (United States); Cristianne Fernandez, Rebecca Kwasinski, Kevin Leiva, Florida International Univ. (United States); Francisco Perez-Clavijo, Podiatry Care Partners Inc. (United States); Anuradha Godavarty, Florida International Univ. (United States)
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Study of amides in blood plasma and tissues of oral cancer using polarised Raman spectroscopy
Paper 10873-5
Time: 9:40 AM - 10:00 AM
Author(s): Manjula Gunasekaran, Vijayaraghavan Srinivasan, Paterson Cancer Ctr. (India); Aruna Prakasa Rao, Ganesan Singaravelu, Anna Univ., Chennai (India)
Show Abstract
Coffee Break 10:00 AM - 10:30 AM
Session 2:
Optical Bioassay Platforms II
Tuesday 5 February 2019
10:30 AM - 11:50 AM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
Lingyan Shi, Columbia Univ. (United States)
Cholesterol esterification inhibition suppresses prostate cancer metastasis by impairing the Wnt/β-catenin pathway (Invited Paper)
Paper 10873-6
Time: 10:30 AM - 11:00 AM
Author(s): Hyeon Jeong Lee, Ji-Xin Cheng, Boston Univ. (United States)
Show Abstract
Evaluation of variations in plasma collagen NADH and Flavin in pre and post treated breast Cancer patients using native fluorescence spectroscopy
Paper 10873-7
Time: 11:00 AM - 11:20 AM
Author(s): Chithra Krishnamoorthy, Vijayaraghavan Srinivasan, Paterson Cancer Ctr. (India); Aruna Prakasa Rao, Ganesan Singaravelu, Anna Univ., Chennai (India)
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DO-SRS imaging of metabolic dynamics in animals (Invited Paper)
Paper 10873-8
Time: 11:20 AM - 11:50 AM
Author(s): Lingyan Shi, Chaogu Zheng, Yihui Shen, Wei Min, Columbia Univ. (United States)
Show Abstract
Lunch/Exhibition Break 11:50 AM - 1:20 PM
Session 3:
Optical Histology I
Tuesday 5 February 2019
1:20 PM - 3:10 PM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
J. Stewart Russell, The City College of New York (United States)
Towards the 3D digital optical histology (Invited Paper)
Paper 10873-9
Time: 1:20 PM - 1:50 PM
Author(s): Francesco Saverio Pavone, LENS - Lab. Europeo di Spettroscopie Non-Lineari (Italy)
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Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application (Invited Paper)
Paper 10873-10
Time: 1:50 PM - 2:20 PM
Author(s): Renzhe Bi, Ghayathri Balasundaram, Malini Olivo, Dinish U.S., Singapore Bioimaging Consortium (Singapore); Seungwan Jeon, Pohang Univ. of Science and Technology (Korea, Republic of); Toru Imai, Caltech (United States); Lai Guan Ng, Immunos, Agency for Science, Technology and Research (A*STAR) (Singapore); Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of); Lihong Wang, Caltech (United States)
Show Abstract
Microscale photoacoustic spectroscopy using integrated photonics for lab-on-chip applications
Paper 10873-11
Time: 2:20 PM - 2:40 PM
Author(s): Robin Singh, Lionel Kimerling, Anu Agarwal, Brian W. Anthony, Massachusetts Institute of Technology (United States)
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Multi-parametric photoacoustic microscopy (Invited Paper)
Paper 10873-12
Time: 2:40 PM - 3:10 PM
Author(s): Song Hu, Univ. of Virginia (United States)
Show Abstract
Coffee Break 3:10 PM - 3:40 PM
Session 4:
Optical Histology II
Tuesday 5 February 2019
3:40 PM - 5:30 PM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
Stavros G. Demos, Univ. of Rochester (United States)
Optical biopsy of vocal folds during phonation using parallel OCT
Paper 10873-13
Time: 3:40 PM - 4:00 PM
Author(s): Gopi N. Maguluri, Physical Sciences Inc. (United States); Daryush D. Mehta, James B. Kobler, Ctr. for Laryngeal and Voice Rehabilitation, Massachusetts General Hospital (United States); Jesung Park, Nicusor V. Iftimia, Physical Sciences Inc. (United States)
Show Abstract
OCT for core biopsy guidance: a rabbit study
Paper 10873-14
Time: 4:00 PM - 4:20 PM
Author(s): Nicusor V. Iftimia, Gopi N. Maguluri, Jesung Park, Physical Sciences Inc. (United States); Sharjeel Sabir, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Show Abstract
Hyperspectral stimulated Raman scattering microscopy for molecular subtyping of glioblastomas
Paper 10873-15
Time: 4:20 PM - 4:40 PM
Author(s): Bae Kideogg, Wei Zheng, Kan Lin, National Univ. of Singapore (Singapore); Carol Tang, Christopher Beng Ti Ang, National Univ. of Singapore (Singapore), National Neuroscience Institute (Singapore); Zhiwei Huang, National Univ. of Singapore (Singapore)
Show Abstract
Deep-UV excitation fluorescence imaging for rapid and accurate detection of lymph node metastasis in human gastric cancer (Invited Paper)
Paper 10873-16
Time: 4:40 PM - 5:10 PM
Author(s): Tatsuya Matsumoto, Yasuaki Kumamoto, Kyoto Prefectural Univ. of Medicine (Japan); Hirohiko Niioka, Osaka Univ. (Japan); Hideo Tanaka, Kyoto Prefectural Univ. of Medicine (Japan); Jun Miyake, Osaka Univ. (Japan); Tetsuro Takamatsu, Kyoto Prefectural Univ. of Medicine (Japan)
Show Abstract
Improving intensity-based virtual H&E from fluorescence imaging with deep learning
Paper 10873-17
Time: 5:10 PM - 5:30 PM
Author(s): Faisal Mahmood, Johns Hopkins Univ. (United States); Katherine N. Elfer, Tulane Univ. (United States); Daniel Borders, Johns Hopkins Univ. (United States); Bihe Hu, J. Quincy Brown, Tulane Univ. (United States); Nicholas J. Durr, Johns Hopkins Univ. (United States)
Show Abstract
Session PTues:
Posters-Tuesday
Tuesday 5 February 2019
6:00 PM - 8:00 PM
Location: Marriott Marquis Hotel, Golden Gate Ballroom

Conference attendees are invited to attend the poster session on Tuesday evening. Come view the posters, enjoy light refreshments, ask questions, and network with colleagues in your field.

Poster Setup: Tuesday 10:00 AM – 5:00 PM
View poster presentation guidelines and set-up instructions at
http://spie.org/PWPosterGuidelines
Optical characterization of pteridine and its derivatives: a potential biomarker for oral cancer diagnosis
Paper 10873-38
Time: 6:00 PM - 8:00 PM
Author(s): Brindha Elumalai, Anna Univ., Chennai (India), Dire Dawa Univ. (Ethiopia); Rajasekaran Ramu, Dire Dawa Univ. (Ethiopia), Anna Univ., Chennai (India); Aruna Prakasa Rao, Anna Univ., Chennai (India); Biniyum Girma, Dire Dawa Univ. (Ethiopia); Ganesan Singaravelu, Anna Univ., Chennai (India)
Show Abstract
Near-infrared Raman spectroscopy of tissue and urine samples of normal, oral premalignant and malignant conditions: a comparative study
Paper 10873-39
Time: 6:00 PM - 8:00 PM
Author(s): Brindha Elumalai, Rajasekaran Ramu, Anna Univ., Chennai (India), Dire Dawa Univ. (Ethiopia); Aruna Prakasa Rao, Anna Univ., Chennai (India); Efrem Mengistu, Dire Dawa Univ. (Ethiopia); Ganesan Singaravelu, Anna Univ., Chennai (India)
Show Abstract
Distinguish chromophobe renal cell carcinoma and renal oncocytoma based on analysis of multiphoton microscopic images using convolutional neural network
Paper 10873-40
Time: 6:00 PM - 8:00 PM
Author(s): Michael Icaza, Nicolas Judd, Southern Connecticut State Univ. (United States); Manu Jain, Memorial Sloan-Kettering Cancer Ctr. (United States); Sushmita Mukherjee, Weill Cornell Medicine (United States); Binlin Wu, Southern Connecticut State Univ. (United States)
Show Abstract
Breast cancer diagnosis using fluorescence spectroscopy and machine learning algorithms
Paper 10873-41
Time: 6:00 PM - 8:00 PM
Author(s): Xin Gao, LaGuardia Community College (United States); Binlin Wu, Southern Connecticut State Univ. (United States)
Show Abstract
Deconvolution of Stokes shift spectrum of human blood samples for the identification of potential biomarkers for early oral cancer diagnosis
Paper 10873-43
Time: 6:00 PM - 8:00 PM
Author(s): Brindha Elumalai, Rajasekaran Ramu, Anna Univ., Chennai (India), Dire Dawa Univ. (Ethiopia); Aruna Prakasa Rao, Ganesan Singaravelu, Anna Univ., Chennai (India)
Show Abstract
Quantitative spectroscopy of collagen and water in infrared windows I, III, and IV as an aid to targeted application of skin therapeutics
Paper 10873-44
Time: 6:00 PM - 8:00 PM
Author(s): Vivian Wang, Stewart Russell, Robert R. Alfano, Institute for Ultrafast Laser and Spectroscopy, The City College of New York (United States)
Show Abstract
Optimal NIR and SWIR optical parameters for absorption and SHG detecting deep tissue vessels in intestinal submucosa
Paper 10873-45
Time: 6:00 PM - 8:00 PM
Author(s): Shirley Chan, Min Jing Zheng, The City College of New York (United States); Tiffany Chou, The City College of New York (United States); Stewart Russell, Robert R. Alfano, The City College of New York (United States)
Show Abstract
Human glioma grading by characterization using label free fluorescence spectroscopy
Paper 10873-46
Time: 6:00 PM - 8:00 PM
Author(s): Yan Zhou, The General Hospital of the Air Force, PLA (China); Cheng-Hui Liu, Institute for Ultrafast Spectroscopy and Lasers, The City Univ. of New York (United States); Ke Zhu, Institute of Physics, Chinese Academy of Sciences (China); Binlin Wu, CSCU Ctr. for Nanotechnology, Southern Connecticut State Univ. (United States); Xinguang Yu, Gangge Cheng, Rui Zong, Mingyue Zhao, Jichun Zheng , The General Hospital of the Air Force, PLA (China); Chunyuan Zhang, Institute for Ultrafast Spectroscopy and Lasers, The City College of New York (United States); Hong Chen, Shenglin Li, Qijun Liang, Mingqian Zhang, China Academy of Space Technology (China); Robert R. Alfano, Institute for Ultrafast Spectroscopy and Lasers, The City College of New York (United States)
Show Abstract
Detecting triple negative breast cancer using second harmonic generation imaging and resonance Raman spectroscopy
Paper 10873-47
Time: 6:00 PM - 8:00 PM
Author(s): Jason T. Smith, Rensselaer Polytechnic Institute (United States); Ethan Bendau, Lin Zhang, Institute for Ultrafast Spectroscopy and Lasers, The City College of New York (United States); Ellen Ackerstaff, Memorial Sloan-Kettering Cancer Ctr. (United States); Natalia Kruchevsky, Memorial Sloan Kettering Cancer Ctr. (United States); Robert R. Alfano, Institute for Ultrafast Spectroscopy and Lasers, The City College of New York (United States); Jason Koutcher, Memorial Sloan-Kettering Cancer Ctr. (United States), Memorial Sloan Kettering Cancer Ctr. (United States), Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Ctr. (United States); Lingyan Shi, Columbia Univ. (United States), Institute for Ultrafast Spectroscopy and Lasers, The City College of New York (United States)
Show Abstract
Alzheimer’s disease: label-free fluorescence shows increases in indoleamine 2,3-dioxygenase (IDO) activity in affected areas of the brain
Paper 10873-48
Time: 6:00 PM - 8:00 PM
Author(s): Laura A. Sordillo, The City College of New York (United States); Lin Zhang, Peter Sordillo, Robert R. Alfano, Institute for Ultrafast Spectroscopy and Lasers, The City College of New York (United States)
Show Abstract
Microscopy with ultraviolet surface excitation (MUSE) enables translation of optical biopsy principles to enhance life science education
Paper 10873-49
Time: 6:00 PM - 8:00 PM
Author(s): Katherine A. Kopp, Stavros G. Demos, Univ. of Rochester (United States)
Show Abstract
Raman and resonance Raman scattering probes energy transfer in beta-carotene solutions and mixed solvents
Paper 10873-50
Time: 6:00 PM - 8:00 PM
Author(s): Richard Brun, The City College of New York (United States)
Show Abstract
Wednesday 6 February Show All Abstracts
Session 5:
Spectroscopic Methods I
Wednesday 6 February 2019
8:20 AM - 10:00 AM
Location: Room 156 (South Upper Mezzanine)
Session Chairs:
Yang Pu, MicroPhotoAcoustics, Inc. (United States) ;
Min Xu, Fairfield Univ. (United States)
Innovative and high-performance instrumentation for biomedical Mueller polarimetric imaging in vivo
Paper 10873-18
Time: 8:20 AM - 8:40 AM
Author(s): Arvid Lindberg, Jeremy Vizet, Camille Gennet, Camille Petite, Ecole Polytechnique (France); Jean Rehbinder, ICube, Univ. de Strasbourg (France); Jean-Charles Vanel, Angelo Pierangelo, Ecole Polytechnique (France)
Show Abstract
Perspectives of optical diagnosis with vector light beams
Paper 10873-19
Time: 8:40 AM - 9:00 AM
Author(s): Alexander Doronin, Victoria Univ. (New Zealand); Nicolas Vera, Juan Staforelli, Univ. de Concepción (Chile); Tatiana Novikova, CNRS (France), Ecole Polytechnique (France), Univ. Paris-Saclay (France); Igor Meglinski, Univ. of Oulu (Finland)
Show Abstract
Non-invasive in vivo measurements of muscle stiffness in Drosophila POMT model using Brillouin elastography
Paper 10873-21
Time: 9:00 AM - 9:20 AM
Author(s): Maria A. Troyanova-Wood, Vladislav Yakovlev, Texas A&M Univ. (United States)
Show Abstract
Diffuse reflectance spectroscopy biomarkers for biological tissues characterization: application to ex-vivo animal tissues
Paper 10873-22
Time: 9:20 AM - 9:40 AM
Author(s): Félix Fanjul-Vélez, José L. Arce-Diego, Univ. de Cantabria (Spain)
Show Abstract
Application of smoothing splines for spectroscopic analysis in hyperspectral images
Paper 10873-23
Time: 9:40 AM - 10:00 AM
Author(s): Asgeir Bjorgan, Lise L. Randeberg, Norwegian Univ. of Science and Technology (Norway)
Show Abstract
Coffee Break 10:00 AM - 10:30 AM
Session 6:
Spectroscopic Methods II
Wednesday 6 February 2019
10:30 AM - 12:00 PM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
Francesco Saverio Pavone, LENS - Lab. Europeo di Spettroscopie Non-Lineari (Italy)
Segmented cell data analysis of autofluorescent signal of endogenous molecules in mitochondria vs cytoplasm (Invited Paper)
Paper 10873-24
Time: 10:30 AM - 11:00 AM
Author(s): Ruofan Cao, Horst Wallrabe, Ammasi Periasamy, Univ. of Virginia (United States)
Show Abstract
Feasibility of a snapshot hyperspectral imaging for detection of local skin oxygenation
Paper 10873-25
Time: 11:00 AM - 11:20 AM
Author(s): Labrinus van Manen, Leiden Univ. Medical Ctr. (Netherlands); Willem Birkhoff, Ctr. for Human Drug Research (Netherlands); Jeroen Eggermont, Leiden Univ. Medical Ctr. (Netherlands); Koos Burggraaf, Ctr. for Human Drug Research (Netherlands); Alexander Vahrmeijer, Sven Mieog, Leiden Univ. Medical Ctr. (Netherlands); Dominic Robinson, Leiden Univ. Medical Ctr. (Netherlands), Erasmus Medical Center (Netherlands); Jouke Dijkstra, Leiden Univ. Medical Ctr. (Netherlands)
Show Abstract
Separating fluorescence from Raman spectra using a CMOS SPAD TCSPC line sensor for biomedical applications
Paper 10873-26
Time: 11:20 AM - 11:40 AM
Author(s): Andrea Usai, Neil Finlayson, Christopher D. Gregory, Colin Campbell, Robert K. Henderson, The Univ. of Edinburgh (United Kingdom)
Show Abstract
Machine learning assisted blood vessel segmentation in laser speckle imaging
Paper 10873-27
Time: 11:40 AM - 12:00 PM
Author(s): Audrey Benmergui, Jonas Drotleff, Tony Pan, Josh Zwiebel, Ilya Kuznetsov, Weizmann Institute of Science (Israel); Igor Meglinski, Univ. of Oulu (Finland); Alon Harmelin, Vyacheslav Kalchenko, Weizmann Institute of Science (Israel)
Show Abstract
Lunch/Exhibition Break 12:00 PM - 1:00 PM
Session 7:
SWIR and IR Methods I
Wednesday 6 February 2019
1:00 PM - 3:00 PM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
Lingyan Shi, Columbia Univ. (United States)
Advances in medical applications using SWIR light in the wavelength range from 1600 to 2350 nm (Invited Paper)
Paper 10873-28
Time: 1:00 PM - 1:30 PM
Author(s): Laura A. Sordillo, Lingyan Shi, Diana Sordillo, Peter Sordillo, Robert R. Alfano, Institute for Ultrafast Spectroscopy and Lasers, The City College of New York (United States)
Show Abstract
Mid-infrared spectroscopic imaging to assess wounded tissue health
Paper 10873-29
Time: 1:30 PM - 1:50 PM
Author(s): Ben O. Mellors, Hamid Dehghani, The Univ. of Birmingham (United Kingdom); Chris R. Howle, Abigail M. Spear, Defence Science and Technology Lab. (United Kingdom)
Show Abstract
Metasurface enhanced infrared reflection spectroscopy for the observation of live cancer cells
Paper 10873-30
Time: 1:50 PM - 2:10 PM
Author(s): Steven H. Huang, Shourya Dutta Gupta, Robert Delgado, Kelly Hume, Gennady B. Shvets, Cornell Univ. (United States)
Show Abstract
Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics (Invited Paper)
Paper 10873-31
Time: 2:10 PM - 2:40 PM
Author(s): Shuo Chen, RIKEN Ctr. for Brain Science (Japan); Xiaogang Liu, National Univ. of Singapore (Singapore); Thomas McHugh, RIKEN Ctr. for Brain Science (Japan)
Show Abstract
Mid-infrared OCT imaging in highly scattering samples using real-time upconversion of broadband supercontinuum covering from 3.6-4.6 μm
Paper 10873-51
Time: 2:40 PM - 3:00 PM
Author(s): Christian Rosenberg Petersen, Niels M. Israelsen, DTU Fotonik (Denmark), NORBLIS (Denmark); Ajanta Barh, Deepak Jain, Mikkel Jensen, DTU Fotonik (Denmark); Günther Hannesschläger, RECENDT (Austria); Peter Tidemand-Lichtenberg, Christian Pedersen, DTU Fotonik (Denmark), NLIR ApS (Denmark); Adrian Podoleanu, University of Kent (United Kingdom); Ole Bang, DTU Fotonik (Denmark), NORBLIS (Denmark)
Show Abstract
Coffee Break 3:00 PM - 3:30 PM
Session 8:
SWIR and IR Methods II
Wednesday 6 February 2019
3:30 PM - 6:00 PM
Location: Room 156 (South Upper Mezzanine)
Session Chair:
Angela B. Seddon, The Univ. of Nottingham (United Kingdom)
Hyperspectral characterization of tissue in the SWIR spectral range: a road to new insight? (Invited Paper)
Paper 10873-32
Time: 3:30 PM - 4:00 PM
Author(s): Lise L. Randeberg, Norwegian Univ. of Science and Technology (Norway)
Show Abstract
Spectral cytopathology in a rapidly flowing cell mixture: combining cell-selective dielectrophoresis with metasurface-enhanced infrared spectroscopy (Invited Paper)
Paper 10873-34
Time: 4:00 PM - 4:30 PM
Author(s): Gennady B. Shvets, Glen Kelp, Joy Li, Junlan Lu, Robert Delgado, Cornell Univ. (United States); Shourya Dutta Gupta, Cornell Univ. (United States), Indian Institute of Technology Hyderabad (India)
Show Abstract
Widefield measurements of water and lipids with label-free short-wave spatial frequency domain imaging (Invited Paper)
Paper 10873-35
Time: 4:30 PM - 5:00 PM
Author(s): Darren M. Roblyer, Yanyu Zhao, Matthew Applegate, Boston Univ. (United States); Mark Pierce, Rutgers, The State Univ. of New Jersey (United States)
Show Abstract
Mid-infrared fiber sources for real-time biomedical sensing (Invited Paper)
Paper 10873-36
Time: 5:00 PM - 5:30 PM
Author(s): Robert I. Woodward, Matthew R. Majewski, Gayathri Bharathan, Darren D. Hudson, Alex Fuerbach, Stuart D. Jackson, Macquarie Univ. (Australia)
Show Abstract
Progress in biomedical mid-infrared hyperspectral imaging with fibre-based supercontinuum laser light (Invited Paper)
Paper 10873-37
Time: 5:30 PM - 6:00 PM
Author(s): Angela B. Seddon, The Univ. of Nottingham (United Kingdom)
Show Abstract
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