Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis

The goal of this conference is to present novel, state-of-the-art work in non-invasive spectroscopic and imaging methods to detect the onset and progression of disease, including pre-malignancy and malignancy, and intra-operatively, and tissue and cells’ response to external conditions, including therapeutic intervention, unintended injury, and laser energy deposition. The conference will focus on work investigating the differences in single and multiphoton excitation optical signatures of normal and diseased tissues, and on understanding the underlying biochemical and structural changes of tissues and cells responsible for the observed spectroscopic signatures. There will also be a fast spectral data processing focus, with a view to real-time diagnostics through spectra, and including reservoir computing, biomimetic approaches, machine learning, and kernel methods, like SVMs (support-vector-machines). It is worth noting that this conference has hosted in recent years a number of contributions on the detection of disease using optical spectroscopy signatures of body fluids such as urine or blood plasma. As the field of metabolomics continues to grow, it is possible that “optical metabolomics” maybe a new frontier in the field of Optical Biopsy. Complex light, quantum effects and entanglement biomedical analysis of tissue, cells and structural components is a new thrust in Optical Biopsy.

This conference covers a wide array of well-established optical techniques and novel approaches to diagnose tissues changes, including in vivo and ex vivo fluorescence spectroscopy, Stokes shift spectroscopy, spectral imaging, Raman spectroscopy, Stimulated Raman, resonance Raman, multiphoton and photonic methods to modify the tissue and body fluid properties or functions implemented in vivo or ex-vivo covering the technology development steps from bench-to-bedside, at the point of need. Compact pill smart spectral explorers, multi-spectral imagers, coherence effects, and hyper-spectral imaging will be highlighted and covered, in part, by speakers.

Topics include:

• origin of tissue optical properties
• optical methods for tissue diagnosis and treatment
• methods for in vivo assessment of physiological state of tissue
• excitation, absorption, fluorescence spectroscopy and imaging
• Mid-infrared (MIR) absorption spectroscopy and hyperspectral imaging
• Raman spectroscopy and imaging
• Resonance Raman spectroscopy
• inelastic light scattering spectroscopy and imaging
• Stimulated Raman gain spectroscopy and imaging
• polarization and diffusive reflectance spectral imaging
• THz spectroscopy and imaging
• photoluminescence spectroscopy and imaging
• multi-photon spectroscopy and imaging
• time resolved spectroscopy and imaging
• speckle and spatial Fourier frequency spectroscopy for diagnoses
• ultraviolet diagnostic methods
• near-infrared (NIR) diagnostic methods
• nano-particle tagging and contrast agents
• chemo- and molecular targeting agents
• instrumentation of in vivo optical biopsy
• in vivo spectroscopy and imaging
• optical processes at the single cell level
• endoscopes and micro-endoscopes for optical biopsy: visible to THz
• novel methods for optical biopsy
• optical biopsy mapping with linear excitation methods
• nonlinear optical biopsy mapping
• novel coherence methods
• instrumentation for in-vivo optical biopsy
• video spectral imaging and mapping of tissue
• STED nano-scale imaging
• non-invasive detection and imaging of cancer
• diabetes non-invasive detection
• assessment of tissue injury
• photonic applications in neuro-science
• optical methods for brain diseases, Autism, Alzheimer
• optical metabolomics
• supercontinuum for medical and biological applications
• Stokes shift spectroscopy
• upper excite states for deeper penetration in tissue and brain
• NIR optical windows in 700 nm to 2500nm
• MIR optical window 3 µm to 25 µm
• coherent and non- contact photo-acoustic imaging
• tissue modification with light pulses
• laser tissue welding and real time monitoring
• Complex Vector Vortex light propagation and imaging
• dynamics of laser-tissue interactions
• integration of optical detection and therapy systems
• high resolution imaging methods for in vivo pathology
• rapid tissue microstructure imaging with intrinsic or extrinsic mechanisms
• lipidomics
• fluorescence lifetime imaging (FLIM)
• phosphorescence lifetime imaging (PLIM)
• FLIM of fast metabolic effects
• NADH / FAD fluorescence
• Clinical FLIM applications
• advanced multiphoton imaging
• in-vivo multiphoton tomography of human skin and others
• in-vivo FLIM of the human retina
• protein interaction
• time-resolved spectroscopy
• NEW event thrust on fast spectral data processing focus, with a view to real-time diagnostics through spectra, and including reservoir computing, biomimetic approaches, machine learning, and kernel methods, like SVMs (support-vector-machines) and AI.
• NEW optical metabolomics detection
• NEW complex light on tissues, cells and structures: quantum effects and entanglement