The Moscone Center
San Francisco, California, United States
1 - 6 February 2020
Conference 11251
Label-free Biomedical Imaging and Sensing (LBIS) 2020
Saturday - Tuesday 1 - 4 February 2020
Conference
Committee
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Conference Chairs
Program Committee
  • Shi-Wei Chu, National Taiwan Univ. (Taiwan)
  • Adam de la Zerda, Stanford Univ. School of Medicine (United States)
  • Pietro Ferraro, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
  • Jochen R. Guck, TU Dresden (Germany)
  • Bahram Jalali, Univ. of California, Los Angeles (United States)
  • Ori Katz, The Hebrew Univ. of Jerusalem (Israel)
  • Alexander T. Khmaladze, Univ. at Albany (United States)

Program Committee continued...
  • Pierre P. Marquet, Ctr. de Recherche de l'Univ. Laval Robert-Giffard (Canada)
  • Aydogan Ozcan, Univ. of California, Los Angeles (United States)
  • Jürgen Popp, Friedrich-Schiller-Univ. Jena (Germany)
  • Francisco E. Robles, Georgia Institute of Technology & Emory Univ. School of Medicine (United States)
  • Melissa C. Skala, Univ. of Wisconsin-Madison (United States)
  • Valery V. Tuchin, Saratov State Univ. (Russian Federation), Tomsk State Univ. (Russian Federation), Institute of Precision Mechanics and Control of the RAS (Russian Federation)
  • Yihui Wu, Changchun Institute of Optics, Fine Mechanics and Physics (China)
  • Yizheng Zhu, Virginia Polytechnic Institute and State Univ. (United States)

Saturday 1 February Show All Abstracts
Opening Remarks
Saturday 1 February 2020
8:00 AM - 8:30 AM

Opening remarks by Conference Chairs
Session 1:
Spontaneous Raman I
Saturday 1 February 2020
8:30 AM - 10:00 AM
Session Chairs:
Natan T. Shaked, Tel Aviv Univ. (Israel) ;
Oliver Hayden, Technische Univ. München (Germany)
Rapid theranostics by multicontast spectroscopy/imaging (Keynote Presentation)
Paper 11251-1
Author(s): Jürgen Popp, Leibniz-Institut für Photonische Technologien e.V. (Germany)
Show Abstract
Detection of the differentiation state of salivary gland organoids for tissue engineering by Raman spectroscopy
Paper 11251-2
Author(s): Ting Chean Khoo, Nicholas Moskwa, Georgios A. Athanassiadis, Anna V. Sharikova, Melinda Larsen, Alexander Khmaladze, Univ. at Albany (United States)
Show Abstract
1064 nm Raman microscopy using a multifocal excitation pattern
Paper 11251-3
Author(s): Haojie Ji, Marcos A. Soares de Oliveira, Che-Wei Chang, James W. Chan, Univ. of California, Davis (United States)
Show Abstract
Quantitative monitoring of live cell engineered bone in 3D printed resorbable calcium-phosphate implant in vitro using fiber-optic Raman spectroscopy
Paper 11251-4
Author(s): Anders R. Walther, Morten Ø. Andersen, Martin A. B. Hedegaard, Univ. of Southern Denmark (Denmark)
Show Abstract
Session 2:
Spectroscopy and Scattering I
Saturday 1 February 2020
10:30 AM - 12:30 PM
Intracellular Doppler spectroscopy for label-free functional imaging of living tissue (Invited Paper)
Paper 11251-5
Author(s): David D. Nolte, Purdue Univ. (United States)
Show Abstract
Highly sensitive low-frequency Raman spectroscopy enabled by Sagnac-enhanced impulsive stimulated Raman scattering
Paper 11251-6
Author(s): Walker Peterson, The Univ. of Tokyo (Japan); Kotaro Hiramatsu, The Univ. of Tokyo (Japan), Japan Science and Technology Agency (Japan); Keisuke Goda, The Univ. of Tokyo (Japan), Japan Science and Technology Agency (Japan), Univ. of California, Los Angeles (United States)
Show Abstract
Towards intracellular phase transitions in ALS disease by noncontact Brillouin microscopy
Paper 11251-7
Author(s): Giuseppe Antonacci, IMEC (Belgium)
Show Abstract
High resolution spectral measurements of the numerical aperture induced effects in Brillouin imaging
Paper 11251-8
Author(s): Roni Shaashoua, Alberto Bilenca, Ben-Gurion Univ. of the Negev (Israel)
Show Abstract
Label-free classification of acute myeloid Leukemia by Raman with microsphere assisted imaging (Invited Paper)
Paper 11251-9
Author(s): Yihui Wu, Mingbo Chi, Changchun Institute of Optics, Fine Mechanics and Physics (China); Huaming Xing, Wenchao Zhou, Changchun Institute of Optics, Fine Mechanics, and Physics (China)
Show Abstract
Spectral phasor analysis of autofluorescence responses from cells embedded in turbid media containing collagen
Paper 11251-10
Author(s): Max Kreider, Andrew I. Rodriguez, Karthik Vishwanath, Paul Urayama, Miami Univ. (United States)
Show Abstract
Lunch Break 12:30 PM - 2:00 PM
Session 3:
Autofluorescence, Nonlinear, and Multiphoton Imaging
Saturday 1 February 2020
2:00 PM - 5:30 PM
Session Chair:
Melissa C. Skala, Morgridge Institute for Research (United States)
Quantitative melanin imaging using label-free third-harmonic-generation enhancement-ratio microscopy (Invited Paper)
Paper 11251-11
Author(s): Chi-Kuang Sun, National Taiwan Univ. (Taiwan); Yi-Hua Liao, National Taiwan Univ. Hospital (Taiwan)
Show Abstract
High performance time-resolved fluorescence spectroscopy imager for breast tumor margin visualization
Paper 11251-20
Author(s): Bartosz J. Bortnik, Ruo Yu Gu, Himantha De Silva, Farnaz Dadmanesh, Armando Giuliano, Keith L. Black, Pramod V. Butte, Cedars-Sinai Medical Ctr. (United States)
Show Abstract
Assessment of neuropathology of Alzheimer’s disease brain with high-resolution, label-free multi-harmonic generation microscopy
Paper 11251-13
Author(s): Sandeep Chakraborty, Pei-Che Wu, Sheng-Tse Chen, National Taiwan Univ. (Taiwan); Ming-Jang Chiu, National Taiwan Univ. Hospital (Taiwan); Chi-Kuang Sun, National Taiwan Univ. (Taiwan)
Show Abstract
Real-time intraoperative diagnosis by deep neural network driven multiphoton virtual histology
Paper 11251-14
Author(s): Sixian You, Yi Sun, Jaena Park, Haohua Tu, Marina Marjanovic, Stephen A. Boppart, Beckman Institute for Advanced Science and Technology (United States)
Show Abstract
Multispectral characterisation of mesenchymal stem cells: Age, cell cycle, senescence and pluripotency
Paper 11251-15
Author(s): Jared M. Campbell, ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia), The Univ. of New South Wales (Australia); Abbas Habibalahi, Saabah B. Mahbub, The Univ. of New South Wales (Australia); Martin E. Gosnell, Quantitative Pty Ltd. (Australia), The Univ. of New South Wales (Australia); Ayad G. Anwer, The Univ. of New South Wales (Australia); Sharon Paton, The Univ. of Adelaide (Australia); Stan Gronthos, Mesenchymal Stem Cell Lab. (Australia); Ewa M. Goldys, The Univ. of New South Wales (Australia)
Show Abstract
Resonant second harmonic generation microscopy for molecular level chirality detection (Invited Paper)
Paper 11251-16
Author(s): Shi-Wei Chu, National Taiwan Univ. (Taiwan)
Show Abstract
Label-free investigation of human collagen morpho-mechanics by correlative SHG, Brillouin and Raman microscopy
Paper 11251-17
Author(s): Raffaella Mercatelli, Sara Mattana, Istituto Nazionale di Ottica (Italy); Laura Capozzoli, Istituto di Chimica dei Composti OrganoMetallici (Italy); Fulvio Ratto, Francesca Rossi, Roberto Pini, Istituto di Fisica Applicata "Nello Carrara" (Italy); Daniele Fioretto, Univ. degli Studi di Perugia (Italy); Francesco S. Pavone, Univ. degli Studi di Firenze (Italy), LENS - Lab. Europeo di Spettroscopie Non-Lineari (Italy); Silvia Caponi, Istituto dei Materiali, Consiglio Nazionale delle Ricerche (Italy); Riccardo Cicchi, Istituto Nazionale di Ottica (Italy), LENS - Lab. Europeo di Spettroscopie Non-Lineari (Italy)
Show Abstract
Label-free multispectral monitoring of functional state: from embryos to human articular cartilage tissue
Paper 11251-18
Author(s): Saabah B. Mahbub, The Univ. of New South Wales (Australia), ARC Ctr. of Excellence for Nanoscale Biophotonics (Australia); Jared M. Campbell, The Univ. of New South Wales (Australia), ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia); Tiffany C. Y. Tan, Kylie R. Dunning, The Univ. of Adelaide (Australia), ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia); Abbas Habibalahi, Michael Bertoldo, Dale Goss, Lindsay Wu, The Univ. of New South Wales (Australia); Ewa M. Goldys, The Univ. of New South Wales (Australia), ARC Ctr. of Excellence for Nanoscale BioPhotonics (Australia)
Show Abstract
Probing the metabolic interaction of pancreatic tumor and stroma by label-free optical redox imaging
Paper 11251-12
Author(s): Rupsa Datta, Morgridge Institute for Research (United States); Allison Lau, Sharanya Sivananda, Matthew Vander Heiden, The David H. Koch Institute for Integrative Cancer Research (United States); Melissa C. Skala, Morgridge Institute for Research (United States), Univ. of Wisconsin-Madison (United States)
Show Abstract
Ex vivo assessment of the optical characteristics of human brain and tumour tissue
Paper 11251-19
Author(s): Jonathan Shapey, Univ. College London (United Kingdom); Yijing Xie, Elham Nabavi, King's College London (United Kingdom); Efthymios Maneas, Univ. College London (United Kingdom); Shakeel R. Saeed, Ear Institute, Univ. College London (United Kingdom); Neil Dorward, Neil Kitchen, National Hospital for Neurology & Neurosurgery (United Kingdom); Adrien E. Desjardins, Univ. College London (United Kingdom); Sébastien Ourselin, King's College London (United Kingdom); Zane Jaunmuktane, Sebastian Brandner, Univ. College London (United Kingdom); Robert Bradford, National Hospital for Neurology & Neurosurgery (United Kingdom); Tom Vercauteren, King's College London (United Kingdom)
Show Abstract
Session HT:
BiOS Hot Topics
Saturday 1 February 2020
7:00 PM - 9:00 PM
Sunday 2 February Show All Abstracts
Session 4:
OCT and Interferometry
Sunday 2 February 2020
8:00 AM - 10:15 AM
Session Chair:
Natan T. Shaked, Tel Aviv Univ. (Israel)
Label free optical cell and tissue characterization for veterinary pathology and teratology (Invited Paper)
Paper 11251-21
Author(s): Jürgen Schnekenburger, Álvaro Barroso Pena, Björn Kemper, Westfälische Wilhelms-Univ. Münster (Germany)
Show Abstract
Digital focusing and image registration for resolution-preserving angular compounding in optical coherence tomography (OCT)
Paper 11251-22
Author(s): Jingjing Zhao, Yonatan Winetraub, Edwin Yuan, Orr Zohar, Adam de la Zerda, Stanford Univ. (United States)
Show Abstract
Wide-field intraoperative polarization sensitive and angiographic optical coherence tomography of in vivo non-human primate peripheral nerve
Paper 11251-23
Author(s): Mohsen Erfanzadeh, Massachusetts General Hospital (United States), Harvard Medical School (United States); Ahhyun S. Nam, Marek Hansdorfer, Kasey Kwong, Mark A. Randolph, Robert W. Redmond, Massachusetts General Hospital (United States); Benjamin J. Vakoc, Massachusetts General Hospital (United States), Harvard Medical School (United States)
Show Abstract
Laguerre Gauss modes for speckle reduction while extending depth of docus of optical coherence tomography
Paper 11251-24
Author(s): Yonatan Winetraub, Edwin Yuan, Adam de la Zerda, Stanford Univ. (United States)
Show Abstract
Label-free imaging of a novel zebrafish cancer model
Paper 11251-25
Author(s): Ryan Sentosa, Medizinische Univ. Wien (Austria); Caterina Sturtzel, Martin Distel, St. Anna Kinderkrebsforschung e.V. (Austria); Wolfgang Drexler, Rainer A. Leitgeb, Angelika Unterhuber, Marco Andreana, Medizinische Univ. Wien (Austria)
Show Abstract
Seeing the unseen in patients: Advancing disease prevention and treatment through microimaging (Keynote Presentation)
Paper 11251-26
Author(s): Guillermo J. Tearney, Massachusetts General Hospital (United States)
Show Abstract
Session 5:
Special Panel: New Horizons in Clinical Applications of Label-Free Imaging and Sensing
Sunday 2 February 2020
10:40 AM - 12:20 PM
Lunch Break 12:20 PM - 1:50 PM
Session 6:
Plasmonics and Biosensors
Sunday 2 February 2020
1:50 PM - 3:35 PM
Session Chair:
Yihui Wu, Changchun Institute of Optics, Fine Mechanics and Physics (China)
Label-free imaging of exosomes using depth scanning correlation interferometric microscopy (Invited Paper)
Paper 11251-27
Author(s): Ugur Aygun, Koç Univ. (Turkey); Ayca Yalcin Ozkumur, Bahçesehir Univ. (Turkey); Naside Gozde Durmus, Utkan Demirci, Stanford Univ. (United States); Hakan Ürey, Koç Univ. (Turkey)
Show Abstract
Optical biosensing of mycobacterium tuberculosis for point-of-care diagnosis
Paper 11251-28
Author(s): Charles Maphanga, Sello L. Manoto, Saturnin S. Ombinda-Lemboumba, Council for Scientific and Industrial Research (South Africa); Patience T. Mthunzi-Kufa, Council for Scientific and Industrial Research (South Africa), Univ. of South Africa (South Africa), Univ. of KwaZulu-Natal (South Africa)
Show Abstract
Semi-supervised deep machine learning for rapid antimicrobial susceptibility testing from vibrational spectroscopy data
Paper 11251-29
Author(s): Regina Ragan, Univ. of California, Irvine (United States)
Show Abstract
Highly sensitive & selective detection of organophosphate nerve agent and pesticide based on a reusable liquid-crystal optical sensor
Paper 11251-30
Author(s): Fengjie He, Univ. of Nevada, Las Vegas (United States); Xingliang Xiong, Chongqing Medical Univ. (China); Hui Zhao, Shengjie Zhai, Univ. of Nevada, Las Vegas (United States)
Show Abstract
Plasmonic imaging - from parallel acquisition to actual structural imaging, how to overcome the propagation effect limit? (Invited Paper)
Paper 11251-31
Author(s): Michael T. Canva, CNRS (France), Univ. de Sherbrooke (Canada)
Show Abstract
Session 7:
Photoacoustics and Acousto-optics
Sunday 2 February 2020
4:00 PM - 5:15 PM
Session Chair:
Yihui Wu, Changchun Institute of Optics, Fine Mechanics and Physics (China)
Broadband photoacoustic microscopy based on surface plasmonic sensing (Invited Paper)
Paper 11251-32
Author(s): Xiao-Cong Yuan, Shenzhen Univ. (China)
Show Abstract
Label-free photothermal phase microscopy of live cells (Invited Paper)
Paper 11251-33
Author(s): Yizheng Zhu, Joseph G. Thomas, Shichao Chen, Virginia Polytechnic Institute and State Univ. (United States)
Show Abstract
Observational study of label-free image-guided hyperspectral imaging of Necrotising Entrocolitis (NEC) in neonates
Paper 11251-34
Author(s): Elham Nabavi, King's College London (United Kingdom); Iain Yardley, Evelina Children's Hospital (United Kingdom); Michael Ebner, King's College London (United Kingdom); Jonathan Shapey, Univ. College London (United Kingdom); David Edwards, Tom Vercauteren, King's College London (United Kingdom)
Show Abstract
Session PLN:
BiOS Sunday Plenary
Sunday 2 February 2020
7:15 PM - 8:00 PM
Monday 3 February Show All Abstracts
Session 8:
Polarization and Dark-Field
Monday 3 February 2020
8:00 AM - 9:30 AM
Session Chair:
Yihui Wu, Changchun Institute of Optics, Fine Mechanics and Physics (China)
Instant polarized light microscopy for real-time wide-field visualization of collagen architecture
Paper 11251-35
Author(s): Po-Yi Lee, Bin Yang, Ziyi Zhu, Fengting Ji, Yi Hua, Bryn Brazile, Ian A. Sigal, Univ. of Pittsburgh (United States)
Show Abstract
GRIN lens based polarization endoscope – from conception to application
Paper 11251-36
Author(s): Chao He, Univ. of Oxford (United Kingdom); Jintao Chang, Tsinghua Univ. (China); Honghui He, Shenzhen Key Lab. for Minimal Invasive Medical Technologies (China); Shaoxiong Liu, Shenzhen Sixth People's Hospital (China); Daniel S. Elson, Imperial College London (United Kingdom); Hui Ma, Tsinghua Univ. (China); Martin J. Booth, Univ. of Oxford (United Kingdom)
Show Abstract
How to choose and optimize a classifier for your polarimetric imaging data?
Paper 11251-37
Author(s): Jean Rehbinder, Christian Heinrich, Univ. de Strasbourg (France); Angelo Pierangelo, Lab. de Physique des Interfaces et des Couches Minces (France), Ecole Polytechnique (France), Univ. Paris Saclay (France); Jihad Zallat, Univ. de Strasbourg (France)
Show Abstract
Digital histology of tissue with Mueller polarimetric microscopy
Paper 11251-38
Author(s): Hee Ryung Lee, Lab. de Physique des Interfaces et des Couches Minces (France), CNRS (France); Pengcheng Li, Hui Ma, Tsinghua Univ. (China); Christian Lotz, Florian Kai Groeber-Becker, Sofia Dembski, Universitätsklinikum Würzburg (Germany), Fraunhofer-Institut für Silicatforschung ISC (Germany); Razvigor Ossikovski, Tatiana Novikova, Lab. de Physique des Interfaces et des Couches Minces (France), CNRS (France)
Show Abstract
Label-free super-resolution microsphere-assisted microscopy of biological samples
Paper 11251-39
Author(s): Sylvain Lecler, Lab. des sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (France), Institut National des Sciences Appliquées de Strasbourg (France); Stéphane Perrin, Lab. des sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (France), CNRS (France); Giorgio Quaranta, Ctr. Suisse d'Electronique et de Microtechnique SA (Switzerland), Ecole Polytechnique Fédérale de Lausanne (Switzerland); Nadia Messaddeq, Nicolas Lemercier, Jean-Luc Vonesch, Institut de génétique et de biologie moléculaire et cellulaire (France), Univ. de Strasbourg (France), Institut National de la Santé et de la Recherche Médicale (France); Paul Montgomery, Lab. des sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (France), Univ. de Strasbourg (France), CNRS (France)
Show Abstract
Scalable analysis of architecture of brain tissue with label-free imaging and deep learning
Paper 11251-40
Author(s): Syuan-Ming Guo, Chan Zuckerberg Biohub (United States); Matt Keefe, David Shin, Univ. of California, San Francisco (United States); Jenny Folkesson, Anitha Krishnan, Chan Zuckerberg Biohub (United States); Tomasz Nowakowski, Univ. of California, San Francisco (United States), Chan Zuckerberg Biohub (United States); Shalin B. Mehta, Chan Zuckerberg Biohub (United States)
Show Abstract
Session 9:
Spectroscopy and Scattering II
Monday 3 February 2020
9:30 AM - 10:30 AM
Session Chair:
Oliver Hayden, Technische Univ. München (Germany)
Multiplexed spatial-spectral imaging (Invited Paper)
Paper 11251-41
Author(s): Yuan Luo, National Taiwan Univ. (Taiwan)
Show Abstract
Label free morphochemical characterization of tissues
Paper 11251-42
Author(s): Francesco S. Pavone, LENS - Lab. Europeo di Spettroscopie Non-Lineari (Italy)
Show Abstract
Clinical stratification of peripheral edema using Short Wave Infrared (SWIR) molecular chemical imaging
Paper 11251-43
Author(s): Aaron Smith, Shona D. Stewart, ChemImage Corp. (United States); Arash Samiei, Allegheny General Hospital (United States); Arjun S. Bangalore, Heather Gomer, Marlena Darr, Robert C. Schweitzer, Christopher Post, Patrick J. Treado, ChemImage Corp. (United States); Jeffrey Cohen, Allegheny General Hospital (United States)
Show Abstract
Session 10:
Coherent Raman
Monday 3 February 2020
11:00 AM - 1:15 PM
Session Chair:
Francisco E. Robles, Georgia Institute of Technology & Emory Univ. School of Medicine (United States)
Label-free chemical microscopy for Life science and translational medicine (Keynote Presentation)
Paper 11251-44
Author(s): Ji-Xin Cheng, Boston Univ. (United States)
Show Abstract
Rapid switching between various wavelength regions for coherent Raman imaging with a robust all-fiber source
Paper 11251-45
Author(s): Tim Hellwig, Maximilian Brinkmann, Westfälische Wilhelms-Univ. Münster (Germany), Refined Laser Systems UG (Germany); Carsten Fallnich, Westfälische Wilhelms-Univ. Münster (Germany), Cells-in-Motion Cluster of Excellence (Germany)
Show Abstract
Why nonlinear Raman microspectroscopy is more than just a gimmick?
Paper 11251-46
Author(s): Vladislav V. Yakovlev, Texas A&M Univ. (United States)
Show Abstract
Two new approaches to broadband stimulated Raman scattering microscopy
Paper 11251-47
Author(s): Alejandro De La Cadena Perez Gallardo, Carlo Michele Valensise, Daniele Viola, Giulio N. Cerullo, Dario Polli, Politecnico di Milano (Italy)
Show Abstract
Novel microscope objective lens for all colors
Paper 11251-48
Author(s): Adam M. Hanninen, Eric O. Potma, Univ. of California, Irvine (United States); Rongguang Liang, Univ. of Arizona (United States)
Show Abstract
Fingerprint–to-CH stretch region high spectral resolution Stimulated Raman Scattering microscopy with an Acousto Optical Tunable Filter
Paper 11251-49
Author(s): Sergey P. Laptenok, Luca Genchi, Vijayakumar P. Rajamanickam, Andrea Bertoncini, Alessandro Giammona, Carlo Liberale, King Abdullah Univ. of Science and Technology (Saudi Arabia)
Show Abstract
High-resolution multimodal flexible coherent Raman endoscope
Paper 11251-50
Author(s): Hervé Rigneault, Viktor Tsvirkun, Vasyl Mytskaniuk, Aix-Marseille Univ. (France), Institut Fresnel (France), CNRS (France); Marc Fabert, Frédéric Louradour, Univ. de Limoges (France), XLIM (France); Alexandre Kudlinski, Lab de Physique des Lasers, Atomes et Molécules (France), Univ. de Lille (France)
Show Abstract
Lunch Break 1:15 PM - 2:45 PM
Session 11:
Spontaneous Raman II
Monday 3 February 2020
2:45 PM - 4:15 PM
Session Chair:
Alexander Khmaladze, Univ. at Albany (United States)
Sensitivity analysis of wavefront shaping based Raman endoscopy
Paper 11251-51
Author(s): Liubov Amitonova, Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)
Show Abstract
Raman hyperspectral imaging of transferrin-bound iron in T47D and MDA-MB-231 breast cancer cells
Paper 11251-52
Author(s): Ting Chean Khoo, Univ. at Albany (United States); Kate Tubbesing, Alena Rudkouskaya, Albany Medical College (United States); Georgios A. Athanassiadis, Anna V. Sharikova, Univ. at Albany (United States); Margarida Barroso, Albany Medical College (United States); Alexander Khmaladze, Univ. at Albany (United States)
Show Abstract
Multimodal, label-free histopathology for improving the diagnosis of Hirschsprung disease
Paper 11251-53
Author(s): Marcos A. Soares de Oliveira, Laura A. Galganski, Che-Wei Chang, Christopher D. Pivetti, Karen E. Matsukuma, Bo Zhang, Alexandro Lopez, Payam Saadai, James W. Chan, Univ. of California, Davis (United States)
Show Abstract
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling
Paper 11251-54
Author(s): Conor C. Horgan, Anika Nagelkerke, Thomas E. Whittaker, Valeria Nele, Lucia Massi, Ulrike Kauscher, Jelle Penders, Mads S. Bergholt, Imperial College London (United Kingdom); Steve R. Hood, GlaxoSmithKline (United Kingdom); Molly M. Stevens, Imperial College London (United Kingdom)
Show Abstract
Session PMon:
Posters-Monday
Monday 3 February 2020
5:30 PM - 7:00 PM

Conference attendees are invited to attend the BiOS poster session on Monday evening. Come view the posters, enjoy light refreshments, ask questions, and network with colleagues in your field.

Poster Setup: Monday 10:00 AM – 4:30 PM
View poster presentation guidelines and set-up instructions at
http://spie.org/PWPosterGuidelines
Scanning Offset-Emission Hyperspectral Microscopy (SOHM) of waveguiding in single ZnO nanorod
Paper 11251-76
Author(s): Bonghwan Chon, National Institute of Standards and Technology (United States), Georgetown Univ. (United States); Johnson T. Truong, Matthew Hansen, Jong-in Hahm, Georgetown Univ. (United States); Young Jong Lee, National Institute of Standards and Technology (United States)
Show Abstract
Study of the red blood cell aggregation by coherent anti-Stokes Raman spectroscopy
Paper 11251-77
Author(s): Martín A. Toderi, Gustavo E. Galizzi, Bibiana D. Riquelme, Instituto de Física Rosario (Argentina), Univ. Nacional de Rosario (Argentina); Dominique Dumas, Univ. de Lorraine (France), CNRS (France), Institut National de la Santé et de la Recherche Médicale (France)
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A label-free study of focal adhesions using deep learning in interference reflection microscopy
Paper 11251-78
Author(s): Lisa Sophie Kölln, Univ. of Strathclyde (United Kingdom); Carsten G. Hansen, The Univ. of Edinburgh (United Kingdom); Gail McConnell, Univ. of Strathclyde (United Kingdom)
Show Abstract
Epithelial mesenchymal transition of prostate cancer cells monitored with a photonic cystal biosensor
Paper 11251-79
Author(s): Melissa Cadena, Frank De Luna, The Univ. of Texas at San Antonio (United States); Lu-Zhe Sun, The Univ. of Texas Health Science Ctr. at San Antonio (United States); Jing Yong Ye, The Univ. of Texas at San Antonio (United States)
Show Abstract
High-speed digital holography for monitoring the Daphnia heart rate in environmental toxicity test
Paper 11251-80
Author(s): Sang-Won Lee, Ik Hwan Kwon, Tae Geol Lee, Korea Research Institute of Standards and Science (Korea, Republic of)
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Line scan Raman microspectroscopy for label-free diagnosis of ex vivo pituitary adenoma biopsies
Paper 11251-81
Author(s): Daniela Bovenkamp, Jeremias Püls, Fabian Placzek, Alexander Micko, Stefan Wolfsberger, Romana Höftberger, Greisa Vila, Rainer A. Leitgeb, Wolfgang Drexler, Marco Andreana, Angelika Unterhuber, Medizinische Univ. Wien (Austria)
Show Abstract
In vivo optical coherence tomography of cerebral microvessels in medaka
Paper 11251-82
Author(s): Takashi Suzuki, Tomohiro Ueno, Naoya Oishi, Kyoto Univ. Graduate School of Medicine (Japan); Hidenao Fukuyama, Beijing Institute of Technology Human Brain Research Lab. and Intelligent Robotics Institute (China), Nagoya City Univ. Graduate School of Medical Sciences and Medical School (Japan)
Show Abstract
Snapshot polarization microscopy for imaging of brain tissue
Paper 11251-83
Author(s): Marco Augustin, Antonia Lichtenegger, Johanna Gesperger, Pablo Eugui, Adelheid Wöhrer, Bernhard Baumann, Medizinische Univ. Wien (Austria)
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Label-free ultrasensitive detection of Amyloid-β using microtoroid resonators for early detection of Alzheimer’s disease
Paper 11251-84
Author(s): Adley Gin, Phuong-Diem Nguyen, Judith Su, The Univ. of Arizona (United States)
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Birefringence microscopy for imaging the structural integrity of myelin
Paper 11251-85
Author(s): Nathan Blanke, Irving J. Bigio, Boston Univ. (United States)
Show Abstract
Volumetric visualization of spinal cord using optical coherence tomography and tissue clearing technique
Paper 11251-86
Author(s): Woohee Shin, Ga Hyang Lee, Yujin Ahn, Kibeom Park, Hyunmo Yang, Woonggyu Jung, Ulsan National Institute of Science and Technology (Korea, Republic of)
Show Abstract
Real-time measurement of hemoglobin concentration in continuous-wave diffusion optical spectroscopy using the least-squares method
Paper 11251-87
Author(s): Yikeun Kim, Pukyong National Univ. (Korea, Republic of); Chang Su Kim, Hyung Hwan Moon, Kosin Univ. (Korea, Republic of); HyunSeo Park, Pukyong National Univ. (Korea, Republic of); Eun-Kee Park, Kosin Univ. (Korea, Republic of); Yeh-Chan Ahn, Pukyong National Univ. (Korea, Republic of)
Show Abstract
Quantitative analysis of the microvasculature flow speed using optical coherence tomography angiography technique and variable interscan time algorithm
Paper 11251-88
Author(s): Ting-Hao Chen, Ting-Yen Tsai, Yin-Peng Huang, Chuan-Bor Chueh, Meng-Shan Wu, Yi-Chun Wu, Ching-Yu Wang, Yi-Ping Hung, National Taiwan Univ. (Taiwan); Meng-Tsan Tsai, Chang Gung Univ. (Taiwan); Hsiang-Chieh Lee, National Taiwan Univ. (Taiwan)
Show Abstract
A sub-sampling image acquisition strategy for single pixel imaging with low signal-to-noise ratio
Paper 11251-89
Author(s): Fangyuan Sha, Nanyang Technological Univ. (Singapore); Sujit K. Sahoo, Nanyang Technological Univ. (Singapore), Indian Institute of Technology Goa (India); Cuong H. Dang, Nanyang Technological Univ. (Singapore)
Show Abstract
Low cost smartphone-based colposcopy for early detection of uterine cervical cancer
Paper 11251-90
Author(s): Yeh-Chan Ahn, Pukyong National Univ. (Korea, Republic of)
Show Abstract
Computer-aided label-free fluorescence lifetime skin cancer screening
Paper 11251-91
Author(s): Renan A. Romano, Ramon G. T. Rosa, Instituto de Física de São Carlos (Brazil); Ana Gabriela Salvio, Hospital Amaral Carvalho (Brazil); Javier A. Jo, Texas A&M Univ. (United States), The Univ. of Oklahoma (United States); Cristina Kurachi, Instituto de Física de São Carlos (Brazil)
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Enhancement of label-free biosensing of cardiac troponin I
Paper 11251-93
Author(s): Chase Christenson, Kwaku Baryeh, The Univ. of Texas at San Antonio (United States); Samad Ahadian, Rohollah Nasiri, Mehmet R. Dokmeci, Marcus Goudie, Ali Khademhosseini, Univ. of California, Los Angeles (United States); Jing Yong Ye, The Univ. of Texas at San Antonio (United States)
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Deep learning algorithms enable the automated chondrocyte viability assessment of cartilage with autofluorescence and second harmonic generation imaging
Paper 11251-94
Author(s): Tong Ye, Xun Chen, Yang Li, Nicole Wyman, Clemson Univ. (United States)
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Polarization recovery in full thickness bone allows for discrimination of diseased state
Paper 11251-95
Author(s): Emily G. Pendleton, Ruth P. Barrow, Ana D. Maslesa, Kayvan F. Tehrani, Luke J. Mortensen, The Univ. of Georgia (United States)
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A highly uniform nanogap SERS sensor with a high sensitivity
Paper 11251-96
Author(s): Samir Adhikari, Jongmin Lee, Yudong Jang, Yeongsoon Jeong, Chanwoo Hong, Ilsun Yoon, Donghan Lee, Chungnam National Univ. (Korea, Republic of)
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3D printed portable holographic microscope for biomedical particle ensemble investigations
Paper 11251-97
Author(s): Nikolay V. Petrov, Alexandra O. Georgieva, Dmitriy V. Ladaniy, Alexander P. Khurchak, ITMO Univ. (Russian Federation)
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Label-free ex-vivo intravital 3D imaging of human hair follicles with optical coherence tomography
Paper 11251-98
Author(s): Janin Lehmann, Monasterium Lab. Skin & Hair Research Solutions GmbH (Germany); Álvaro Barroso Pena, Björn Kemper, Jürgen Schnekenburger, Westfälische Wilhelms-Univ. Münster (Germany); Ralf Paus, Monasterium Lab. Skin & Hair Research Solutions GmbH (Germany), Univ. of Manchester (United Kingdom); Marta Bertolini, Monasterium Lab. Skin & Hair Research Solutions GmbH (Germany); Jeremy Chéret, Univ. of Miami (United States), Monasterium Lab. Skin & Hair Research Solutions GmbH (Germany)
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Ultrafast plasmonic and real-time label-free polymerase chain reaction
Paper 11251-99
Author(s): Padideh Mohammadyousef, Andrew G. Kirk, McGill Univ. (Canada); Miltiadis Paliouras, Mark Trifiro, Lady Davis Institute for Medical Research, Jewish General Hospital (Canada)
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Label-free characterization of mitochondria assembly in oocyte of Caenorhabditis elegans by two-photon excited autofluorescence
Paper 11251-100
Author(s): Tao Chen, Yi-tang Lee, Dinghuan Deng, Meng C. Wang, Baylor College of Medicine (United States)
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Raman spectroscopy and gold thin film for biosensing and detection
Paper 11251-92
Author(s): Saturnin S. Ombinda-Lemboumba, Lebogang Thobakgale, Sello L. Manoto, Masixole Y. Lugongolo, CSIR National Laser Ctr. (South Africa); Patience T. Mthunzi-Kufa, CSIR National Laser Ctr. (South Africa), Univ. of South Africa (South Africa), Univ. of KwaZulu-Natal (South Africa)
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Tuesday 4 February Show All Abstracts
Session 12:
Holography and Phase Microscopy I
Tuesday 4 February 2020
8:00 AM - 10:15 AM
Session Chair:
Oliver Hayden, Technische Univ. München (Germany)
Low latency deep cytometry with realtime inference (Invited Paper)
Paper 11251-55
Author(s): Bahram Jalali, Yueqin Li, Ata Mahjoubfar, Univ. of California, Los Angeles (United States); Kayvan R. Niazi, NantWorks, LLC (United States)
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Holographic analysis of sperm for in vitro fertilization
Paper 11251-56
Author(s): Simcha K. Mirsky, Pinkie J. Eravuchira, Itay Barnea, Lidor Karako, Mattan Levi, Michal Balberg, Hayit Greenspan, Natan T. Shaked, Tel Aviv Univ. (Israel)
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Cell biophysical properties measured with multimodal quantitative-phase digital holographic microscopy
Paper 11251-57
Author(s): Erik Bélanger, Émile Rioux-Péllerin, Sara Mattar, François Paquet-Mercier, Marie-Ève Crochetière, Jean-Xavier Giroux, Pierre P. Marquet, CERVO Brain Research Ctr. (Canada), Univ. Laval (Canada)
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Towards a robust low cost Fourier Ptcyhographic device
Paper 11251-58
Author(s): Alexander Heemels, Temitope E. Agbana, Silvania F. Pereira, Jan-Carel Diehl, Michel Verhaegen, Gleb Vdovin, Technische Univ. Delft (Netherlands)
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Six-pack holography and dynamic synthetic aperture superresolution
Paper 11251-59
Author(s): Simcha K. Mirsky, Natan T. Shaked, Tel Aviv Univ. (Israel)
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Deep learning-enabled holography (Keynote Presentation)
Paper 11251-60
Author(s): Aydogan Ozcan, Univ. of California, Los Angeles (United States)
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Session 13:
Holography and Phase Microscopy II
Tuesday 4 February 2020
10:45 AM - 12:15 PM
Session Chair:
Natan T. Shaked, Tel Aviv Univ. (Israel)
Utilizing digital holographic microscopy for label-free monitoring of blood cell differentiation (Invited Paper)
Paper 11251-61
Author(s): Björn Kemper, Angelika Vollmer, Andreas Bauwens, Westfälische Wilhelms-Univ. Münster (Germany)
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Label-free 3D refractive index interferometric tomography of live cancer cells with full angular coverage.
Paper 11251-62
Author(s): Matan Dudaie, Tel Aviv Univ. (Israel)
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Experimental digital Gabor hologram rendering of C. elegans worms by a model-trained convolutional neural network
Paper 11251-63
Author(s): Michael Atlan, Julie Rivet, Antoine Taliercio, Institut Langevin Ondes et Images (France); Nicolas Boutry, Guillaume Tochon, EPITA (France); Jean-Pierre Huignard, Institut Langevin Ondes et Images (France)
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Full-field interferometric imaging of neuron deformation during action potential
Paper 11251-64
Author(s): Tong Ling, Kevin C. Boyle, Valentina Zuckerman, Thomas Flores, Daniel V. Palanker, Stanford Univ. (United States)
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Neural-network based classification of non-adherent cancer cells using Label free Quantitative Phase Imaging data
Paper 11251-65
Author(s): Silvia Ceballos, Han Sang Park, Will J. Eldridge, Adam P. Wax, Duke Univ. (United States)
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Lunch Break 12:15 PM - 1:45 PM
Session 14:
Holography and Phase Microscopy II
Tuesday 4 February 2020
1:45 PM - 3:15 PM
Session Chair:
Yizheng Zhu, Virginia Polytechnic Institute and State Univ. (United States)
3D computational phase microscopy with multiple-scattering samples (Invited Paper)
Paper 11251-66
Author(s): Laura Waller, Univ. of California, Berkeley (United States)
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Probing live cell T cell in label-free manner using morpho molecular microscopy
Paper 11251-67
Author(s): Rishikesh Pandey, CytoVeris Inc. (United States)
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Label free discrimination and selection of cancer cells during flow
Paper 11251-68
Author(s): Matan Dudaie, Tel Aviv Univ. (Israel)
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Speckle-free quantitative phase microscopy using pseudo-thermal light source for label-free imaging of biological cells and tissues with high temporal phase stability and spatial phase sensitivity
Paper 11251-69
Author(s): Dalip S. Mehta, Indian Institute of Technology Delhi (India)
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Differential detection at extended pupil plane for label-free phase contrast imaging
Paper 11251-70
Author(s): Hari P. Paudel, Clemens Alt, Judith M. Runnels, Charles P. Lin, Massachusetts General Hospital (United States), Harvard Medical School (United States)
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Session 15:
Holography and Phase Microscopy IV
Tuesday 4 February 2020
3:45 PM - 5:15 PM
Session Chair:
Natan T. Shaked, Tel Aviv Univ. (Israel)
Epi-mode tomographic quantitative phase imaging in thick scattering samples (Invited Paper)
Paper 11251-71
Author(s): Francisco E. Robles, Georgia Institute of Technology & Emory Univ. School of Medicine (United States)
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Label-free cell analysis and classification with lens-less computational imaging
Paper 11251-72
Author(s): Duofang Chen, Xixin Luo, Zhaohui Wang, Jimin Liang, Xueli Chen, Xidian Univ. (China)
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Ultraviolet hyperspectral microscopy using chromatic aberration based iterative phase-recovery
Paper 11251-73
Author(s): Nischita Kaza, Ashkan Ojaghi, Georgia Institute of Technology (United States); Francisco E. Robles, Georgia Institute of Technology & Emory Univ. School of Medicine (United States)
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High throughput screening of cancer cells using holographic cytometry
Paper 11251-74
Author(s): Han Sang Park, Will J. Eldridge, Silvia Ceballos, Adam P. Wax, Duke Univ. (United States)
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Digital holographic microscopy (DHM) and transport of intensity (TIE) phase imaging of live cells
Paper 11251-75
Author(s): Shane Carney, Ting Chean Khoo, Jeremy Wittkopp, Kai Pisila, Georgios A. Athanassiadis, Anna V. Sharikova, Alexander Khmaladze, Jonathan C. Petruccelli, Univ. at Albany (United States)
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Concluding Remarks
Tuesday 4 February 2020
5:15 PM - 5:35 PM

Concluding Remarks by Conference Chairs
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