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Proceedings Paper

Effects of La0.2Ce0.6Eu0.2F3 nanoparticles capped with polyethylene glycol on human astrocytoma cells in vitro
Author(s): Nathan J. Withers; Yekaterina Brandt; Antonio C. Rivera; Leisha M. Armijo; Nathaniel C. Cook; Marek Osiński
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Paper Abstract

Lanthanide fluoride colloidal nanocrystals offer a way to improve the diagnosis and treatment of cancer through the enhanced absorption of ionizing radiation, as well as providing visible luminescence. In order to explore this possibility, cytotoxicity assays need to be performed on mammalian cells in vitro, to show minimum levels of biocompatibility for future experiments. 20% lanthanum 60% cerium and 20% europium lanthanide fluoride nanocrystals were capped with polyethylene glycol (PEG) of molecular weight 4000 and suspended in deionized water. These nanocrystals were characterized by transmission electron microscopy, muffle furnace ashing, absorbance spectroscopy, dynamic light scattering, and photoluminescence spectroscopy. Visible light microscopy and trypan blue staining was performed on the cells to assay the cytotoxicity of the nanocrystal on the human astrocytoma line U-87 MG, purchased from ATCC.

Paper Details

Date Published: 2 February 2012
PDF: 9 pages
Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320R (2 February 2012); doi: 10.1117/12.911953
Show Author Affiliations
Nathan J. Withers, The Univ. of New Mexico (United States)
Yekaterina Brandt, The Univ. of New Mexico (United States)
Antonio C. Rivera, The Univ. of New Mexico (United States)
Leisha M. Armijo, The Univ. of New Mexico (United States)
Nathaniel C. Cook, The Univ. of New Mexico (United States)
Marek Osiński, The Univ. of New Mexico (United States)

Published in SPIE Proceedings Vol. 8232:
Colloidal Nanocrystals for Biomedical Applications VII
Wolfgang J. Parak; Kenji Yamamoto M.D.; Marek Osinski, Editor(s)

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