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Proceedings Paper

Electrical property-based biopsy for prostate cancer detection and assessment
Author(s): Ryan J. Halter; Vaishali Mishra; Hamza Bouayad; Preston Manwaring; John Heaney; Alan Schned
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Paper Abstract

Prostate cancer diagnosis is based solely on biopsy-based findings. Unfortunately, routine biopsy protocols only sample ~0.95% of the entire gland limiting the technique's sensitivity to cancer detection. Previous studies have demonstrated significant electrical property differences between malignant and benign prostate tissues due to their dissimilar morphological architectures. We have taken the important step of translating these findings to the clinic by integrating an electrical property sensor into the tip of a standard biopsy needle. This novel device allows clinicians to simultaneously extract a tissue core and assess the electrical properties around the needle tip in real-time. The expected volume of tissue sensed with this device was estimated using finite-element method (FEM) based simulations to model the potential fields and current distributions. Prototype devices have been constructed and evaluated in a series of saline baths in order to validate the FEM-based findings. Simulations suggest that the electrical property sensor is able to interrogate a tissue volume of ~62.1 mm3 and experimental results demonstrated a volume of sensitivity of ~68.7 mm3. This coupled device is being used to assess the increased sensitivity and specificity to cancer detection when electrical properties are sensed in concert with tissue core extraction in a series of 50 ex vivo prostates. Typical 12-core prostate biopsy protocols extract a total tissue volume of 228 mm3 for histological assessment. Employing this electrical property sensor to gauge electrical properties at both the beginning and end of the needle trajectory will provide pathological assessment of an additional 1648 mm3 of tissue.

Paper Details

Date Published: 23 February 2011
PDF: 9 pages
Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010U (23 February 2011); doi: 10.1117/12.876489
Show Author Affiliations
Ryan J. Halter, Dartmouth College (United States)
Dartmouth Medical School (United States)
Norris Cotton Cancer Ctr. (United States)
Vaishali Mishra, Dartmouth College (United States)
Hamza Bouayad, Dartmouth College (United States)
Preston Manwaring, Dartmouth College (United States)
John Heaney, Dartmouth College (United States)
Dartmouth Medical School (United States)
Darmouth-Hitchcock Medical Ctr. (United States)
Alan Schned, Dartmouth Medical College (United States)
Darmouth-Hitchcock Medical Ctr. (United States)
Norris Cotton Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 7901:
Energy-based Treatment of Tissue and Assessment VI
Thomas P. Ryan, Editor(s)

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