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Proceedings Paper

Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis
Author(s): Xiu-Li Wang; Hong-Wei Wang; Ming-Xia Guo; Zheng Huang
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Paper Abstract

To investigate the feasibility and efficacy of combination of imiquimod immunotherapy and 5- aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) for the treatment of genital bowenoid papulosis (BP). A total of twenty seven BP patients were randomized into two groups: (I) fifteen patients (12 male and 3 female, age 22-56 years old) were treated with topical application of 5% imiquimod cream (three times a week) and ALA-PDT (100 J/cm2 at 100 mW/cm2, once a week) for 1-4 times in one week interval. (II) Twelve patients (6 male and 6 female, age 29-58 years old) were treated with CO2 laser vaporization as a control. Patients were followed up for 3 to 12 months. Results: In combined therapy group, 60% (9/15) patients showed complete remission and only one recurred (11.1%) during follow up. Local side effects included mild erythema, edema, erosion and burning and/or stinging sensation. No systemic side effect was found. In CO2 laser vaporization group, 83.3% (10/12) patients showed complete remission. However, recurrence occurred in 6 patients (60.0%). Local side effects included mild to moderate edema, erosion, ulceration, delayed healing, prolonged pain and scarring. The difference of recurrence rate between two groups was statistically significant (P < 0.05). Topical application of imiquimod cream and ALA-PDT is safe, effective and associated with low recurrence and less side effect. Its true clinical value needs to be further investigated by a long-term follow-up of large scale trial.

Paper Details

Date Published: 13 February 2007
PDF: 7 pages
Proc. SPIE 6438, Biophotonics and Immune Responses II, 643809 (13 February 2007); doi: 10.1117/12.698774
Show Author Affiliations
Xiu-Li Wang, Shanghai Skin Diseases and STD Hospital (China)
Hong-Wei Wang, Shanghai Skin Diseases and STD Hospital (China)
Ming-Xia Guo, Shanghai Skin Diseases and STD Hospital (China)
Zheng Huang, Univ. of Colorado at Denver and Health Sciences Ctr. (United States)

Published in SPIE Proceedings Vol. 6438:
Biophotonics and Immune Responses II
Wei R. Chen, Editor(s)

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