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Proceedings Paper

Sparing of normal urothelium in hexyl-aminolevulinate-mediated photodynamic therapy
Author(s): Laurent Vaucher; Patrice Jichlinski; Norbert Lange; Celine Ritter-Schenk; Hubert van den Bergh; Pavel Kucera
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Paper Abstract

This work determines on an in vitro porcine urothelium model the threshold values of different parameters such as photosensitizer concentration, irradiation parameters and production of reactive oxygen species in order to control the damage on normal urothelium and spare about 50% of normal mucosa. For a three hours HAL incubation time, these threshold values were with blue light (0.75J/cm at 75 mW/cm2 or 0.15J/cm2 at 30 mW/cm2) and with white light (0.55J/cm2, at 30 mW/cm2). This means that for identical fluence rates, the threshold value for white light irradiation may be 3 times higher than for blue light irradiation.

Paper Details

Date Published: 25 April 2005
PDF: 6 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005);
Show Author Affiliations
Laurent Vaucher, Univ. Hospital/Lausanne (Switzerland)
Patrice Jichlinski, Univ. Hospital/Lausanne (Switzerland)
Norbert Lange, Univ. of Geneva (Switzerland)
Celine Ritter-Schenk, Univ. of Lausanne (Switzerland)
Hubert van den Bergh, LPAS-EPFL (Switzerland)
Pavel Kucera, Univ. of Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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