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Proceedings Paper

Quantification of fiber orientation uncertainty in polarized light imaging of the human brain
Author(s): Daniel Schmitz; Thomas Lippert; Katrin Amunts; Markus Axer
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Paper Abstract

Three-dimensional Polarized Light Imaging (3D-PLI) enables the investigation of nerve fibers in the brain by probing their birefringence with polarimetric measurements of unstained brain sections. Based on a biophysical model, it allows the estimation of the three-dimensional fiber orientation. In this work, a novel probabilistic approach capable of providing confidence measures for the inferred fiber orientation is introduced. The developed analysis utilizes Bayesian inference to derive a distribution for the model parameters. Simulations show that the obtained confidence measures are accurate. On human brain data, the novel algorithm enables to quantify levels of confidence in 3D-PLI for the first time. The method shows that fiber orientation estimation in 3D-PLI is robust for white matter regions.

Paper Details

Date Published: 16 March 2020
PDF: 9 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 1131239 (16 March 2020); doi: 10.1117/12.2548935
Show Author Affiliations
Daniel Schmitz, Forschungszentrum Jülich (Germany)
Thomas Lippert, Forschungszentrum Jülich (Germany)
Bergische Univ. Wuppertal (Germany)
Katrin Amunts, Forschungszentrum Jülich (Germany)
C. and O. Vogt Institute of Brain Research, Univ. Hospital Düsseldorf (Germany)
Markus Axer, Forschungszentrum Jülich (Germany)

Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

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