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Proceedings Paper

Two-photon Bessel beam scanning microscope for neural activities (Conference Presentation)

Paper Abstract

Neuroscience research is propelled by advance imaging tools, which ideally could provide high spatial and temporal resolution imaging. However, available fast 3-dimensional optical sectioning approaches applicable to deep tissue and large scale in-vivo imaging are still limited. We develop a novel two-photon Bessel beam scanning light sheet microscope, which has two distinct imaging modes: 1) The light-sheet imaging mode enables sub-micron 3D imaging over hundreds of microns field of view, which is well adapted to the neural tissue with complex structure; 2) The projection imaging mode aims to capture fast neural activities at up to 100 volumes per second. Imaging results of various neural specimens will be presented.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11226, Neural Imaging and Sensing 2020, 1122603 (9 March 2020); doi: 10.1117/12.2546526
Show Author Affiliations
Dongli Xu, Stanford Univ. (United States)
Leilei Peng, The Univ. of Arizona (United States)
Jun Ding, Stanford Univ. (United States)


Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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