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Proceedings Paper

Surface enhanced raman spectroscopy on polymer-graphene oxide scaffolds for drug screening applications
Author(s): Lebogang Thobakgale; Sello Manoto; Saturnin Ombinda Lemboumba; Patience Mthunzi-Kufa
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Paper Abstract

Surface enhanced Raman spectroscopy (SERS) has evolved to be a powerful analytical tool for investigating molecular properties of various types of samples. Literature has shown SERS capabilities in both qualitative and quantitative analysis of biomolecules like proteins and DNA as well as single molecules like antiretroviral medication. Central to its application is the synthesis and use of sensing platforms that enhance signal intensity, sensitivity and detection limits. The most popular approach to make such platforms is through fabricating thin film substrates using a combination of polymers and nanomaterials. In this work, we use the self-assembly method to synthesize graphene oxide based scaffolds in a layer-by-layer fashion and characterize them using SERS. The results show a clear difference in Raman spectral fingerprint for the different layers during the self-assembly steps. Lastly, the intensity ratio between the D and G bands of the graphene layer were calculated to measure the layer thickness which was found to be 0.65, this was comparable to thin layer scaffolds reported in literature. Future work will involve the use of atomic force microscopy to confirm surface morphology and layer thickness, followed by screening of antiretroviral medication.

Paper Details

Date Published: 13 February 2020
PDF: 10 pages
Proc. SPIE 11246, Single Molecule Spectroscopy and Superresolution Imaging XIII, 112460X (13 February 2020); doi: 10.1117/12.2546455
Show Author Affiliations
Lebogang Thobakgale, CSIR National Laser Ctr. (South Africa)
Univ. of Kwa-Zulu Natal (South Africa)
Sello Manoto, CSIR National Laser Ctr. (South Africa)
Saturnin Ombinda Lemboumba, CSIR National Laser Ctr. (South Africa)
Patience Mthunzi-Kufa, CSIR National Laser Ctr. (South Africa)
Univ. of South Africa (South Africa)
Univ. of Kwa-Zulu Natal (South Africa)


Published in SPIE Proceedings Vol. 11246:
Single Molecule Spectroscopy and Superresolution Imaging XIII
Ingo Gregor; Felix Koberling; Rainer Erdmann, Editor(s)

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