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Proceedings Paper

In vivo quantification of Bruch's membrane in humans with visible light OCT (Conference Presentation)

Paper Abstract

Bruch’s membrane (BM) and retinal pigment epithelium (RPE) changes, thought to be the earliest signs of impending atrophy in dry age-related macular degeneration (AMD), are subtle and challenging to detect non-invasively. Here, we demonstrate imaging and quantification of BM and RPE thickness in the in vivo human eye using achromatized visible light optical coherence tomography (OCT) in normal human subjects. Our consistent visualization of BM and agreement of thickness values with ranges from prior histological studies is attributed to the increased axial resolution, and potentially also to the enhanced contrast of BM in the visible light range.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180H (9 March 2020); doi: 10.1117/12.2546437
Show Author Affiliations
Tingwei Zhang, Univ. of California, Davis (United States)
Aaron Kho, Univ. of California, Davis (United States)
Vyas Akondi, Stanford Univ. (United States)
Alfredo Dubra, Stanford Univ. (United States)
Vivek Srinivasan, Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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