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Proceedings Paper

High-sensitivity quantitative x-ray phase-contrast computed tomography for biomedical applications (Conference Presentation)
Author(s): Julia Herzen

Paper Abstract

Over the last two decades, phase-contrast X-ray imaging has been demonstrated to provide superior soft-tissue contrast in comparison to conventional attenuation-based X-ray imaging. However, visualizing biomedical soft tissue at high spatial resolution and high image quality still has been limited to brilliant synchrotron radiation sources with its very limited access. Thus, the possibility to perform high-sensitivity X-ray phase-contrast computed tomography with laboratory setups is of great interest for a broad range of high-resolution biomedical applications. We designed and built a grating-based setup using a standard rotating-anode X-ray source and reaching comparable angular sensitivity as synchrotron-based setups. Here, we will demonstrate the performance of our instrument by highlighting the recent results on quantitative biomedical soft-tissue analysis of different human diseases.

Paper Details

Date Published: 17 September 2019
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Proc. SPIE 11113, Developments in X-Ray Tomography XII, 111130T (17 September 2019);
Show Author Affiliations
Julia Herzen, Technische Univ. München (Germany)


Published in SPIE Proceedings Vol. 11113:
Developments in X-Ray Tomography XII
Bert Müller; Ge Wang, Editor(s)

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