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Paper Abstract

In the area of neurosurgical tumor diagnosis, clinical research on photodynamic diagnosis using 5-aminolevulinic acid (5-ALA) has already been undertaken, and the safety of 5-ALA has also been demonstrated. 5-ALA is approved in the diagnosis of brain tumor and bladder tumor by the Ministry of Health, Labour and Welfare. 5-ALA is a natural amino acid contained in a living body and is a precursor of hemoglobin. When absorbed into the body by oral ingestion, porphyrin synthesis by heme synthesis is specifically performed in a tumor-specific manner, and accumulation of fluorescent protoporphyrin IX (pp IX) is observed. However, pp IX is metabolized and disappeared in normal tissues. When tumor tissue is irradiated with excitation light, at the site where pp IX accumulates, it exhibits red fluorescence. We applied 5-ALA for photodynamic diagnostic in thoracic malignancies.

Paper Details

Date Published: 7 August 2019
PDF: 4 pages
Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110702L (7 August 2019); doi: 10.1117/12.2527526
Show Author Affiliations
Yoshinobu Ohsaki, Asahikawa Medical Univ. (Japan)
Ryohei Yoshida, Asahikawa Medical Univ. (Japan)
Takaaki Sasaki, Asahikawa Medical Univ. (Japan)
Shunsuke Okumura, Asahikawa Medical Univ. (Japan)
Yoshinori Minami, Asahikawa Medical Univ. (Japan)
Yoshihiro Kazebayashi, Asahikawa Medical Univ. (Japan)
Noriko Hirai, Asahikawa Medical Univ. (Japan)
Kei Ishibashi, Asahikawa Medical Univ. (Japan)
Nana Yoshida, Asahikawa Medical Univ. (Japan)
Yasushi Yamamoto, Asahikawa Medical Univ. (Japan)
Masahiro Kitada, Asahikawa Medical Univ. (Japan)

Published in SPIE Proceedings Vol. 11070:
17th International Photodynamic Association World Congress
Tayyaba Hasan, Editor(s)

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