Photodynamic therapy (PDT) utilizes the combined action of photosensitizer, light, and molecular oxygen to generate reactive singlet oxygen (¹O₂) to treat various diseases. Photosensitizer is a key component in PDT and its singlet oxygen quantum yield determines the effectiveness of its photodynamic reaction. This study evaluated the singlet oxygen production of a novel water soluble chlorin photosensitizer (YLG-I) using a ¹O₂-specificfluorescence probe - Singlet Oxygen Sensor Green reagent (SOSG). The spectra and singlet oxygen luminescence in different solvents were evaluated using mTHPC as a reference. It was estimated and verified that the singlet oxygen quantum yield of the new photosensitizer YLG-I was at the same level of the potent chlorin sensitizer mTHPC. Preliminary evaluation suggested that YLG-I was a promising photosensitizer for PDT.

Date Published: 22 July 2019
PDF: 3 pages
Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110790L (22 July 2019); doi: 10.1117/12.2526579

Published in SPIE Proceedings Vol. 11079:
Medical Laser Applications and Laser-Tissue Interactions IX
Lothar D. Lilge; Carsten M. Philipp, Editor(s)