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Proceedings Paper

Vascular mesh and diffusive bells: 2D modeling of blood-brain barrier leakage
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Paper Abstract

Fluorescent methods are widely used in studies of the physiology of the brain in general, and in the analysis of the degree of permeability of the blood-brain barrier (BBB) in particular. As recent experimental data show, the spatial patterns of the BBB opening, on the one hand, observed for the whole brain, and on the other, they can be highly localized if one track their from the very beginning. We consider the issues related to image analysis from the point of view of the classification of flowrescent objects, and also propose a technology for simulating BBB leakage based on layer-by-layer modeling of the diffusion process in a heterogeneous spatial template created directly from experimental data.

Paper Details

Date Published: 3 June 2019
PDF: 6 pages
Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 1106712 (3 June 2019); doi: 10.1117/12.2523914
Show Author Affiliations
Kristina V. Rogatina, Saratov State Univ. (Russian Federation)
Anton A. Namykin, Saratov State Univ. (Russian Federation)
Dmitry E. Postnov, Saratov State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11067:
Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions
Dmitry Engelevich Postnov, Editor(s)

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