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Proceedings Paper

Optoacoustic imaging in five dimensions
Author(s): X. Luís Deán-Ben; Sven Gottschalk; Thomas F. Fehm; Daniel Razansky
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Paper Abstract

We report on an optoacoustic imaging system capable of acquiring volumetric multispectral optoacoustic data in real time. The system is based on simultaneous acquisition of optoacoustic signals from 256 different tomographic projections by means of a spherical matrix array. Thereby, volumetric reconstructions can be done at high frame rate, only limited by the pulse repetition rate of the laser. The developed tomographic approach presents important advantages over previously reported systems that use scanning for attaining volumetric optoacoustic data. First, dynamic processes, such as the biodistribution of optical biomarkers, can be monitored in the entire volume of interest. Second, out-of-plane and motion artifacts that could degrade the image quality when imaging living specimens can be avoided. Finally, real-time 3D performance can obviously save time required for experimental and clinical observations. The feasibility of optoacoustic imaging in five dimensions, i.e. real time acquisition of volumetric datasets at multiple wavelengths, is reported. In this way, volumetric images of spectrally resolved chromophores are rendered in real time, thus offering an unparallel imaging performance among the current bio-imaging modalities. This performance is subsequently showcased by video-rate visualization of in vivo hemodynamic changes in mouse brain and handheld visualization of blood oxygenation in deep human vessels. The newly discovered capacities open new prospects for translating the optoacoustic technology into highly performing imaging modality for biomedical research and clinical practice with multiple applications envisioned, from cardiovascular and cancer diagnostics to neuroimaging and ophthalmology.

Paper Details

Date Published: 11 March 2015
PDF: 6 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231M (11 March 2015); doi: 10.1117/12.2080286
Show Author Affiliations
X. Luís Deán-Ben, Technical Univ. of Munich (Germany)
Helmholtz Ctr. Munich (Germany)
Sven Gottschalk, Technical Univ. of Munich (Germany)
Helmholtz Ctr. Munich (Germany)
Thomas F. Fehm, Helmholtz Zentrum München GmbH (Germany)
Daniel Razansky, Technical Univ. of Munich (Germany)
Helmholtz Ctr. Munich (Germany)

Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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