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Proceedings Paper

Miniature optofluidic darkfield microscope for biosensing
Author(s): Zhenyu Li
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Paper Abstract

Darkfield microscopy is an extremely sensitive imaging and sensing modality due to its very low background. Metal nanoparticles as small as 20nm can been detected by darkfield imaging setups. However, traditional darkfield microscopes are bulky and require special illumination condensers, which limits their application in point-of-care biosensing. In this paper, we present a miniaturized darkfield microscope based on liquid metallic on-chip condensers and imaging lenses. This microscope is fully compatible with PDMS microfluidics and can be attached to a smartphone camera to build a complete handheld biosensing system with very high sensitivity and low cost.

Paper Details

Date Published: 19 September 2014
PDF: 7 pages
Proc. SPIE 9198, Ultrafast Nonlinear Imaging and Spectroscopy II, 91980G (19 September 2014); doi: 10.1117/12.2062642
Show Author Affiliations
Zhenyu Li, The George Washington Univ. (United States)

Published in SPIE Proceedings Vol. 9198:
Ultrafast Nonlinear Imaging and Spectroscopy II
Zhiwen Liu, Editor(s)

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