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Proceedings Paper

Photodynamic effect of copper-vapor pumped-dye laser, He-Ne laser, and noncoherent red light to the liver in normal mice
Author(s): Chuannong Zhou; Xuyan Song; Jinsheng Deng; Junlin Liang; Hua Zhang; Wenjia Huang; Tao Liu; Xian-wen Ha
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Paper Abstract

A quantitative comparison of the photodynamic effect of pulsed (copper vapor-pumped dye laser), continuous-wave laser (He-Ne laser), and non-coherent red light (filtered from a halogen lamp) to the liver in normal mice has been carried out. The mice (each group containing 18 - 20 mice) received hematoporphyrin derivative in a dose of 10 mg/kg iv 24 hours prior to light irradiation. The mouse livers were directly irradiated with different red light in a dose of 5, 10, 25, 50, or 100 J/cm2, respectively. Forty-eight hours later the mice were killed, and the depth of liver necrosis was measured using a computer image-analysis system. No necrosis was found in the control liver irradiated with 500 J/cm2 alone. The depth of photodynamic necrosis showed a light dose-dependent response. The mean depth of necrosis of all groups were compared statistically. The Cu-dye laser showed the best effect while the non-coherent light showed the poorest. There were significant differences between non-coherent light and laser irradiated groups, but not between Cu-dye and He-Ne laser groups. The results indicate that among the examined light sources, the Cu-dye laser is most suitable to photodynamic therapy (PDT) of tumors. However, the halogen lamp with a special filter device may still be occasionally used as a light source in PDT if needed.

Paper Details

Date Published: 5 March 1993
PDF: 7 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137015
Show Author Affiliations
Chuannong Zhou, Cancer Institute (China)
Xuyan Song, Cancer Institute (China)
Jinsheng Deng, Cancer Institute (China)
Junlin Liang, Cancer Institute (China)
Hua Zhang, Cancer Institute (China)
Wenjia Huang, Cancer Institute (China)
Tao Liu, Cancer Institute (China)
Xian-wen Ha, Cancer Institute (China)

Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine
Junheng Li M.D., Editor(s)

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