Download samples of SPIE's manuscript format and layout for letter and A4 paper sizes at the links below. The text of these samples detail SPIE's format preferences.
Save the appropriate template to your directory by right-clicking and choosing "Save Target As..." and open the file.
If you download the blank template, input your content directly. Margins are pre-set and style pull-down menus are available in the Word toolbar. See illustration below.
If you download the file containing sample content, input your content over the sample content. Margins are pre-set and style pull-down menus are available in the Word toolbar. See illustration below.