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    Translational Research Presentations

    Nano/Biophotonics BiOS Program Track, LASE, and OPTO
    (ordered by conference and paper number)

    Nanoparticle-based CT imaging technique for stem cell tracking within the brain: application in neuropsychiatric disorders
    Paper 10077-51

    Author(s):  Oshra Betzer, Gonda Multidisciplinary Brain Research Ctr., Bar-Ilan Univ. (Israel), et al.
    Conference 10077: Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV
    Session PMon: Posters-Monday

    Applying cell-based therapy in clinical practice is very challenging; there is a need to uncover the mystery regarding the fate of the transplanted cells. Therefore, we developed a method for longitudinal and quantitative in-vivo cell tracking, based on classical X-ray computed tomography (CT) combined with gold nanoparticles as labeling agents. We applied our technique for imaging of stem cells transplanted in models for depression and drug addiction, which are highly prevalent disorders lacking effective treatment. With our technique we were able to track the cells as they home to distinct depression/addiction related areas and demonstrate that cell-therapy is a beneficial approach for treating neuropsychiatric disorders.

    Dual activity of carbon nanotube/CpG: inhibition of glioma migration and stimulation of macrophages
    Paper 10078-22

    Author(s):  Jacob M. Berlin, City of Hope Beckman Research Institute (United States), et al.
    Conference 10078: Colloidal Nanoparticles for Biomedical Applications XII
    Session 6: NP Applications in Ophtalmology and Neuroscience

    Even when treated with aggressive current therapies, most patients with glioblastoma survive less than two years. We previously reported that single-walled carbon nanotubes (SWCNTs) can be used to dramatically increase the immunotherapeutic efficacy of CpG oligonucleotides in a mouse model of glioma. Recently we showed that the activity observed was due to a complex mixture. Here we show that a simplified SWCNT/CpG construct not only maintains its immunostimulatory property and enhances the migration of macrophages, but surprisingly also inhibits the migration of glioma cells.

    Fabrication and characterization of multi-point side-firing optical fiber by laser micro-ablation
    Paper 10115-26

    Author(s):  Wei-Chuan Shih, Univ. of Houston (United States), et al.
    Conference 10115: Advanced Fabrication Technologies for Micro/Nano Optics and Photonics X
    Session 8: Direct Laser Writing for Biological and Medical Applications: Joint Session with Conferences 10115 and 10095

    Compared to traditional optical fibers, which are designed to transmit light from one end to the other, a multi-point side firing optical fiber can be useful in several applications such as phototherapy, optogenetics brain stimulation and remote sensing. We present the fabrication and characterization of an optical fiber capable of launching light from virtually any point along its circumferential surface by laser micro-ablation. The feasibility of using a 65 µm OD fiber in optogenetics brain neuron stimulation has been assessed using tissue phantom.

    Transmittance through mouse brain tissue with Gaussian and Laguerre Gaussian vortex beams
    Paper 10120-14

    Author(s):  Lingyan Shi, Columbia Univ. (United States), et al.
    Conference 10120: Complex Light and Optical Forces XI
    Session 4: Optical Angular Momentum

    Light transmission of Gaussian (G) and Laguerre-Gaussian (LG) vortex beams in mouse brain tissue are investigated. Transmittance is measured with different orbital angular momentum (OAM) at various tissue thickness. In both ballistic and diffusive regions, transmittances of LG and G beams show no significant difference. The transition point from ballistic to diffusive region for the mouse brain tissue is determined at about 480 μm. The observed transmittance of the LG and G beams shows the independence on OAM modes, which may be attributed to brain tissue’s special structures and interference effects.

    Important Dates

    Abstracts Due
    26 August 2020

    Acceptance Notification
    9 November 2020

    Presentations and
    Manuscripts Due

    12 February 2021

    Author information

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    Journal of Biomedical Optics

    Journal of Biomedical OpticsPublishes peer-reviewed papers that utilize modern optical technology for improved health care and biomedical research.