The Moscone Center
    San Francisco, California, United States
    28 January - 2 February 2017
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    Brain Presentations

    Photonic Therapeutics and Diagnostics
    (ordered by conference and paper number)


    1.6 mm high-NA field-corrected epifluorescence endomicroscope with a chip-on-the-tip of 400x400 pixel resolution and a single-fiber illumination for brain research and later medical applications
    Paper 10040-6

    Author(s):  Gregor Matz, Grintech GmbH (Germany), et al.
    Conference 10040: Endoscopic Microscopy XII
    Session 1: New Techniques

    We present a flexible stand-alone, minimally invasive video-endomicroscope with an outer diameter of 1.6 mm and a length of the rigid tip of 6.7 mm that images hardly accessible regions in-vivo in epifluorescence mode with a NA of 0.7 and an object field of view of 220 µm. The GRIN-lens based and field corrected design combines a single-fiber epi-illumination with a 400x400 pixel chip-on-the-tip sensor. In-vivo observations of subcellular features in genetically modified mouse brains and fluorescent bead images will demonstrate the image capabilities of the probe with high brightness and contrast and fast acquisition speed for later applications.


    High resolution microphotonic needle for endocospic imaging
    Paper 10040-26

    Author(s):  Mohammad Amin Tadayon, Columbia Univ. (United States), et al.
    Conference 10040: Endoscopic Microscopy XII
    Session 6: Novel Imaging Probes

    We introduce a novel micro fabricated needle for endocopy with ultra-high resolution and a FOV equal in size to the whole cross section of the needle. Due to the high index of refraction of the material the measured NA (0.25) of the needle is higher than traditional GRIN lenses. The measured resolution of a few microns and the large field of view, combined with our previous work demonstrating our ability to implant the needle in a live animal, shows that the proposed system can be used for deep tissue imaging with very high resolution and high field of view.


    Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment
    Paper 10045-69

    Author(s):  Ygal Rotenstreich, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel), et al.
    Conference 10045: Ophthalmic Technologies XXVII
    Session PSun: Posters-Sunday

    The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.


    Mass spectrometry imaging applications to characterize and quantify drug distribution in tissue from animal models and clinical trials
    Paper 10046-14

    Author(s):  Nathalie Agar, Brigham and Women's Hospital (United States), et al.
    Conference 10046: Visualizing and Quantifying Drug Distribution in Tissue
    Session 4: Multimodal/Linear Scattering/Mass Spectroscopy/RNA Tools

    An effective targeted therapeutic must both meet criteria for potency, and reach cancer cells at therapeutic levels. In solid tumors of the brain, reaching therapeutic drug levels is limited by the blood-brain barrier, but detailed characterization of drug distribution in the brain has been limited by the lack of tools to directly image small molecules without altering their chemistry with the use of molecular probes. Matrix Assisted Laser Desorption Ionization (MALDI) Fourier Transform Ion Cyclotron Resonance (FTICR) Mass Spectrometry Imaging (MSI) can now be used to characterize and quantitate the distribution of intact small molecules and their metabolites in tissue.


    Identification and localization of trauma-related biomarkers using matrix assisted laser desorption/ionization imaging mass spectrometry
    Paper 10046-15

    Author(s):  Randolph D. Glickman, The Univ. of Texas Health Science Ctr. at San Antonio (United States), et al.
    Conference 10046: Visualizing and Quantifying Drug Distribution in Tissue
    Session 4: Multimodal/Linear Scattering/Mass Spectroscopy/RNA Tools

    Matrix assisted laser-assisted desorption/ionization imaging mass spectrometry (MALDI IMS) is a specialized application of mass spectrometry that not only is well suited to the discovery of novel or unanticipated biomarkers, but also provides information about the spatial localization of biomarkers in tissue. In a rat model of traumatic optic nerve injury, MALDI IMS analysis of tissue sections of retina and optic nerve has shown trauma-related changes in the expression levels of particular protein biomarkers in the injured tissue. These biomarkers may provide clues leading to improved trauma therapies.


    Photobiomodulation and the brain: a new paradigm
    Paper 10048-1

    Author(s):  Michael R. Hamblin, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States), et al.
    Conference 10048: Mechanisms of Photobiomodulation Therapy XII
    Session 1: Mechanisms of Photobiomodulation Therapy I

    Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by humankind in general, is the brain. The brain suffers from many different disorders that can be classified into three broad groupings: traumatic events (stroke, traumatic brain injury, and global ischemia), degenerative diseases (dementia, Alzheimer’s and Parkinson’s), and psychiatric disorders (depression, anxiety, post traumatic stress disorder). This presentation will cover the mechanisms of action of photobiomodulation to the brain, and summarize some of the key pre-clinical studies and clinical trials that have been undertaken in this area.


    Biomedical, translational and clinical research on PDT of TMJ
    Paper 10048-8

    Author(s):  Julia E. Kamenoff, Medical Univ. Sofia (Bulgaria), et al.
    Conference 10048: Mechanisms of Photobiomodulation Therapy XII
    Session 2: Mechanisms of Photobiomodulation Therapy II

    Many authors pay particular attention to the therapeutic effect of PDT and laser acupuncture (LA) for the treatment of chronic disorders in the TMJ. The data in world literature, it is clear that the main problem is the dosage ("Dosage is KEY "). Up to this moment has confirmed the statement that because of poliethyologic nature and the wide variety of symptoms in the TMJ disorders is advisable to combine different methods of PDT, depending on the objective condition of the patients and their individual optical characteristic. In recent years there has dictum: "laser + TENS + magnet = success." The aim of our original biomedical, translational and clinical study was to analyse the real effect of combined therapeutic program in depth and basing on our clinical observations to suggest new approach guaranteeing high therapeutic efficacy of TMJ Photodynamic therapy.


    Challenges of transcutaneous laser application for the potential of photobiomodulation of the spinal cord at the scale of a large companion animal
    Paper 10048-19

    Author(s):  Daqing Piao, Oklahoma State Univ. (United States), et al.
    Conference 10048: Mechanisms of Photobiomodulation Therapy XII
    Session PSun: Posters-Sunday

    This limited study evaluated the transcutaneous delivery to the T13-L1 level of the spinal canal in comparison to that to the cranium of a 40 pound cadaverous dog under the same clinically acceptable surface power. Additionally, the skin-to-muscle and skin-to-spine penetrations at the T12-13, T13-L1, L1-2, L2-3, and L3-4 levels of the spinal canal were measured. Transcutaneous delivery of the irradiance to the shallowest region of the spinal canal seemed to be comparable to transcranial delivery. Transcutaneous delivery to other levels of the spinal canal is challenging, indicating a potentially narrow tissue window for transcutaneous bio-stimulation of the spinal cord.


    Investigation on physiological and clinical effects of different light sources in TMJ laser therapy
    Paper 10048-22

    Author(s):  Julia E. Kamenoff, Medical Univ. Sofia (Bulgaria), et al.
    Conference 10048: Mechanisms of Photobiomodulation Therapy XII
    Session PSun: Posters-Sunday

    Laser light Electromagnetic energy has some typical properties for discussions on laser irradiation abilities to control the acute and chronic disorders in TMJ. During the last six years we have been completed well controlled clinical trials based on the criteria of the American Academy of orofacial pain. The study over the 600 patients (300 women and 300 men), mean age of 47 years have been developed. Patients have been selected on the main clinical sign of TMJ pain and have been divided into four main groups according to the type of PDT method. Based on the action spectra, various wavelengths have been used for TMJ Photodynamic Therapy. Constant dose and time of exposition, as well as various range of frequencies have been applied. In this way the Laser biostimulation response has been directly proportional to the total energy dose, depending of light intensity. Physiological and clinical effects of the followed “active regions”– 660 – 680, 760 – 780, 810 – 830 and 904 – 987 nm have been valued by method of comparative analysis.


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    Journal of Biomedical Optics

    Journal of Biomedical OpticsPublishes peer-reviewed papers that utilize modern optical technology for improved health care and biomedical research.