Photo-active fast ultrasound localization microscopy
24 January 2022 • 10:50 AM - 11:10 AM PST | Room 211 (Level 2 South)
Ultrasound localization microscopy (ULM) maps the locations of moving microbubbles to form a super-resolution image. However, the speed of ULM is slow because it requires thousands of ultrasound images to form one ULM image. We develop a fast photoactive ultrasound localization microscopy (pULM) using laser-activatable nanodroplets as alternative contrast agents. The nanodroplets allow both temporally- and spatially- selective vaporization of nanodroplets into microbubbles. We use block-wise localization with sparsity constraints optimization to improve the localization recovery efficiency significantly from densely packed activated-nanodroplets (microbubbles). With these techniques, we demonstrate an in vivo fast super-resolution imaging in a small animal model.
Univ. of Illinois (United States)
Shensheng Zhao received the bachelor’s degree in mechanical engineering from the University of Science and Technology of China, Hefei, China in 2018. He is currently pursuing the Ph.D. degree with the Department of Electrical and Computer Engineering, University of Illinois at Urbana–Champaign, Urbana, IL, USA. His current research interests include super-resolution ultrasound imaging, photoacoustic tomography and signal processing.