Paper 13292-22
Paper 13292-22
Optical coherence tomography-based measurement of photodamage and assessment of photodamage prevention in murine skin
26 January 2025 • 10:50 AM - 11:10 AM PST | Moscone Center, Room 154 (South Upper Mezz)
Abstract
The development of treatments to reduce photodamage could be an important tool to reducing the prevalence of skin cancer. In this study, we investigate the use of optical coherence tomography (OCT) for assessing photodamage and the efficacy of photodamage prevention treatments. OCT images were acquired monthly on the back, side, and stomach of mice exposed to UVR over a period of 8 months. Two different systemic photodamage prevention treatments were tested: nicotinamide mononucleotide and polypodium leucotomos. Significant differences were observed in the total skin thickness (p=0.027) and optical attenuation coefficient (p<0.001) of the skin between all UVR-exposed mice and the non-exposed control group. Trends over time indicate that the skin-thickening and reduced attenuation occurred at a slower rate in both treatment groups compared with the UVR-exposed control. These results indicate that OCT could be a promising tool for monitoring photodamage in skin.
Presenter
Technical Univ. of Denmark (Denmark), Copenhagen Univ. Hospital (Denmark)
Dr. Gavrielle Untracht is a postdoctoral researcher in the Biophotonic Imaging Group at the Technical University of Denmark and the Department of Dematology, Cophenhagen University Hospital. She received a B.S. in Optical Engineering and an M.S. in Applied Physics from Cornell University. She then obtained a Ph.D. in Biomedical Optics from the University of Western Australia. Her research focuses on exploring light tissue interactions to improve optical imaging towards the development of translational imaging tools. She is driven by the opportunity to make a difference by revolutionizing medical diagnostics.