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Conference 11960 > Paper 11960-45
Paper 11960-45

Label-free photoacoustic computed tomography of visually-evoked hemodynamic responses in the mouse brain

Abstract

The current functional brain mapping techniques such as fMRI and DOI suffer from limited spatial resolution. Photoacoustic (PA) imaging combines the sensitivity of optical imaging to hemodynamic variations, and spatial resolution of ultrasound detection. In this study, we built a label-free PA computed tomography (PACT) system with a ring-shaped ultrasound array to monitor the hemodynamic changes in the primary visual cortex (V1) of mice in response to retinal photostimulation. The responses of wild-type and retinal degenerate (rd1) mice were compared. A linear-array PACT system was also used to measure the visually-evoked subcortical responses. Therefore, PACT is potential tool to study the effect of retinal degeneration of mice on the visual pathway.

Presenter

Univ. of Michigan (United States)
Kai-Wei Chang is a Ph.D. candidate at Department of Biomedical Engineering in the University of Michigan. He received his M.S. degree in Biomedical Electronics and Bioinformatics and B.S. degree in Electrical Engineering from National Taiwan University. His current research focuses on photoacoustic brain imaging.
Presenter/Author
Univ. of Michigan (United States)
Author
Nanjing Univ. (China)
Author
Univ. of Michigan (United States)
Author
Univ. of Michigan (United States)
Author
Univ. of Michigan (United States)