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Conference 11960 > Paper 11960-155
Paper 11960-155

In vitro and in silico studies of bilirubin photodegradation using optoacoustic and fluorescence techniques

Abstract

Hematomas resulted from trauma are very common. Existing treatment techniques have limited efficacy. To improve outcomes, phototherapy (PT) can be used. We studied the effects of phototherapy on bilirubin (BLR) solutions using adsorption (AB) and fluorescent (FL) spectroscopies and optoacoustic (OA). AB, FL, OA signals of BLR-albumin were dependent on exposure time. BLR-albumin absorption decreased exponentially with exposure time, while FL was demonstrated to have complicated dynamics depending on the initial concentration. The results of OA measurements were in good agreement with the in silico study. These results can be used for the optimization of hematomas PT regimes.

Presenter

Skolkovo Institute of Science and Technology (Russian Federation)
Dmitry Gorin is a professor at the Skoltech center of Photonics & Quantum Materials (Moscow, Russia) and head of Biophotonics Lab since 2017. He has received a Diploma of Engineer-Physicist (Specialty: Materials and Components of Solid-State Electronics) in 1997 and his C.Sc. degree and his DSc degree in Physical Chemistry in 2001 and 2011 from Saratov State University, respectively. From 2005 till 2009, he visited Max Planck Institute of Colloids and Interfaces (MPICI). From 2009 till 2010, he worked at the MPICI (Prof. H. Moehwald’s group). He was a professor at the Department of Nano- and Biomedical Technologies at Saratov State University from 2011 till 2017. In 2017 he was awarded Professor in a specialty Biophysics. He was a promoter of 11 C.Sc. and 2 D.Sc. theses. The research interests of Prof. Gorin are in Biophysics, Biophotonics, Theranostics, Physics of Colloids and Interfaces.
Author
Skolkovo Institute of Science and Technology (Russian Federation)
Author
Skolkovo Institute of Science and Technology (Russian Federation)
Author
Saratov State Univ. (Russian Federation)
Author
The Univ. of Texas Medical Branch (United States)
Presenter/Author
Skolkovo Institute of Science and Technology (Russian Federation)