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Conference 11953 > Paper 11953-37
Paper 11953-37

Identification of esophageal cancer by photoelectric biosensors

Abstract

A Lab-on-chip was established to investigate the physical and material properties of p-type and n-type photoelectrochemical (PEC) biosensors. Photoelectric signals were collected from scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Four types of human esophageal cancer cells (ECCs) were used as subjects to analyze the properties of p-type and n-type biosensors. The results showed that the amount of photocurrent measured in advanced cancer stages is smaller than that in early cancer stages. The change in photocurrent response is due to the number of redox reactions carried out by the decline of Glutathione (L-glutathione reduced, GSH) and glutathione disulfide (GSSG) in cancer cells. Our lab-on-chip has enabled identifying ECC stages by determining the level of photocurrent response.

Presenter

National Chung Cheng Univ. (Taiwan)
Hong-Thai Nguyen currently is a research assistant and Phd student in Department of Mechanical Engineering, National Chung Cheng University. His fields of interest and expertise are in Image Processing, Medical Imaging, Multi and Hyper-spectral Imaging.
Presenter/Author
National Chung Cheng Univ. (Taiwan)
Author
Shih-Wei Feng
National Univ. of Kaohsiung (Taiwan)
Author
Nikolaev Institute of Inorganic Chemistry (Russian Federation)
Author
Nikolaev Institute of Inorganic Chemistry (Russian Federation)
Author
Shang-Chin Hsieh
Kaohsiung Armed Forces General Hospital (Taiwan)
Author
Hsiang-Chen Wang
National Chung Cheng Univ. (Taiwan)