Paper 11953-33
Paper 11953-33
IR microfluidics for in situ sensing of molecular interfaces
Abstract
A microfluidic platform coupled to IR spectroscopies for bio-sensing and vibrational spectroscopic investigations of molecular monolayers and their adsorption kinetics is presented. The platform combines metallic island enhancement substrates with microfluidic chips of selectable material and is constructed for IR or Raman microscopic reflection measurements. Involvement of IR laser ellipsometry (acknowledgement to EFRE 1.8/13) potentially allows for sensitive sub-second studies or fast hyperspectral imaging. Various molecular adsorption isotherms during the formation of monolayers on bare or functionalized metallic island surfaces, the adsorption of molecules as well as chemical changes were studied. Potential applications are bio-sensing and bio-medical sensing as well as in the study of processes e.g. enzymatic reactions or chemical reactions, receptor–ligand interactions or structural changes of molecules due to environmental stimuli.
Presenter
Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. (Germany)
Karsten Hinrichs received his PhD in Solid State Physics from the TU Berlin,
Germany and he holds a habilitation degree in Physical Chemistry of the TU
Dresden. Currently he works as researcher and group leader at the Leibniz
institute ISAS e.V.. He is since 2005 elected for the executive board of the
German Working Group Ellipsometry (AKE) and became a member of the
Graduate School of Analytical Sciences at HU Berlin in 2012. In 2016 he was the
program chair of the ICSE-7 and in 2018 editor of the Springer Nature book
“Ellipsometry of functional surfaces and thin films” (2nd edition). Topical research
of him and his team focuses on structure-spectra correlations of functional thin
films and the method development of infrared (IR) nanopolarimetric and IR laserbased
ellipsometry. He is member of the Society for Applied Spectroscopy,
American Chemical Society and German Physical Society. ORCID:
0000-0002-6580-7791, Researcher ID: C-7222-2016