High-speed wide-field functional photoacoustic microscopy of mouse brain actions
We present a new functional photoacoustic microscopy system with the highest imaging speed and ultrawide field of view. The high imaging speed is enabled by a 12-facets polygon for fast scanning and a Raman-shifter system for fast dual-wavelength measurement of oxygen saturation in vivo. we imaged the dynamic functions in mouse brains in response to hypoxia challenge, sodium nitroprusside (SNP), and ischemic stroke. The experimental results have demonstrated that the high-speed photoacoustic microscopy system can be a powerful tool for studying the rapid hemodynamics in the mouse brains of a wide range of pathological and physiological models.
Duke Univ. (United States)
Xiaoyi Zhu received her Ph.D. from the College of Engineering at Peking University. Currently, She is focusing on improving the high-speed widefield OR-PAM system based on a novel immersible hexagon-mirror scanner, and applying the system for clinical research in dermatology, neurology and cancer biology.