High speed volumetric imaging for brain connectomics

Shi-Wei Chu

doi:10.1117/12.2584006

5 March 2021 High speed volumetric imaging for brain connectomics

Shi-Wei Chu

Proceedings Volume 11654, High-Speed Biomedical Imaging and Spectroscopy VI; 1165404 (2021) https://doi.org/10.1117/12.2584006
Event: SPIE BiOS, 2021, Online Only

Abstract

The brain is one of the most important organs in our body, but it is functionally the least understood one. It is composed of millions of neurons, whose interconnection, i.e. connectome, determines its function. Although the interaction of neurons in vitro has been well studied in the past century, no existing tool can capture whole-brain emergent properties at single neuron or even synapse resolution. To understand functional connectome, an imaging system that can cover a whole brain in vivo with spatial resolution of micrometers (neuron) to nanometers (synapse) as well as temporal resolution in sub-seconds (calcium) to milliseconds (action potential) is highly desirable. In this invited talk, we introduce our recent efforts to improve optical microscopy in terms of speed, depth, and spatial resolution, toward the goal of understanding the brain of Drosophila, which offers a small brain with sophisticated functions and genetic control capabilities.

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Citation Download Citation

Shi-Wei Chu "High speed volumetric imaging for brain connectomics", Proc. SPIE 11654, High-Speed Biomedical Imaging and Spectroscopy VI, 1165404 (5 March 2021); https://doi.org/10.1117/12.2584006

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KEYWORDS

Brain

Neuroimaging

Neurons

Spatial resolution

Genetics

Imaging systems

In vitro testing

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