Emulsion-based Hydrogel Phantoms for Assessing Boundary Buildup and Object Detectability in Photoacoustic Imaging
Phantoms were designed to evaluate boundary buildup effect and object detectability. Tissue-mimicking materials simulating breast fat and parenchyma were prepared through emulsification of silicone oil, ethylene glycol and polyacrylamide hydrogel. Imaging targets were prepared by adding either India ink to the water phase or nigrosin to the oil phase. Phantom and inclusion molds were fabricated using an affordable 3D printer, yielding phantoms containing stepped-cylinder inclusions with 1-8 cm-1 optical absorption coefficients and 1-5 mm diameters. Maximum imaging depth depended on whether target boundary buildup or filled-in features were analyzed, with boundary buildup being more detectable.
U.S. Food and Drug Administration (United States)
William Vogt received his BS in mechanical engineering from UMass Amherst in 2009 and his PhD in biomedical engineering from Virginia Tech in 2013. He currently leads FDA’s photoacoustic imaging regulatory science program, which develops tools and test methods for evaluating the safety and effectiveness of photoacoustic imaging devices. His research interests include photoacoustics, tissue phantoms, medical image quality, and standardization.