Fabrication of D-SPR biosensor

Priyanka Thawany; Umesh Tiwari

doi:10.1117/12.2609627

2 March 2022 Fabrication of D-SPR biosensor

Priyanka Thawany, Umesh Tiwari

Proceedings Volume 11953, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXII; 1195305 (2022) https://doi.org/10.1117/12.2609627
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In this paper, a D-optical fiber plasmonic sensor has been demonstrated for highly sensitive detection of refractive index variations. The formation of curvature in the optical fiber is attained by wet etching technique. The D-shape curvature greatly facilitates the excitation of surface plasmons which in turn results in improved sensitivity due to the enhanced coupling of surface plasmon polaritons (SPP) modes at the point of discontinuity. In the process, a 400 micron multimode D-shaped fiber has been coated with a gold film of approximately 50 nm thickness. The sensor has been investigated for the detection of bovine serum albumin (BSA) after immobilizing it with the anti-BSA antibodies. BSA is an important biomarker to predict certain diseases, particularly in cattle. The anti-BSA antibody is conjugated to the mercaptopropionic acid (MPA) modified D-fiber via carbodiimide mediated amide bond formation between the MPA layer and the antibody. The shift in the resonance wavelength of the absorption spectra is studied for measuring the RI variations. The sensitivity of the D-fiber sensor is 1200 nm/RIU. The suitability of this sensor for the protein detection is also explored.

Conference Presentation

Citation Download Citation

Priyanka Thawany and Umesh Tiwari "Fabrication of D-SPR biosensor", Proc. SPIE 11953, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXII, 1195305 (2 March 2022); https://doi.org/10.1117/12.2609627

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