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Roberto Pini

Dr. Roberto  Pini

Senior Scientist
National Research Council of Italy (CNR)

Institute of Applied Physics
Via Madonna del Piano 10

Sesto Fiorentino  50019

tel: +39 055 5225 303
fax: +39 055 5225 305
E-mail: R.Pini@ifac.cnr.it

Area of Expertise

Lasers & LEDS, Microscopies, Nanomedicine, and Theoretical Modeling


Roberto Pini, physicist, is a Senior Scientist at the Institute of Applied Physics (IFAC-CNR) of the CNR in Sesto Fiorentino, where he is the leader the Biophotonics and Nanomedicine Lab (BNLab). He is also a professor at the University of Florence, in charge of a chair of Optics at the Faculty of Medicine and Surgery, and a chair of Biomedical Optics at the Faculty of Optics and Optometry. His main research interests are related to studies on light propagation in biological tissues, development and applications of laser-activated gold nanoparticles and nanostructured chromophores for medical use, microscopic analyses on photothermal modifications of proteins, development of new medical laser devices, preclinical and clinical studies on the use of laser and other optoelectronics devices for minimally invasive surgery (e.g. in ophthalmology, microvascular surgery and dermatology). He is co-author of more than 200 scientific publications, including 6 books, and of 18 patents.

Lecture Title(s)

Laser tissue bonding using ICG and gold nanoparticles

The Paradox of the Eye LensThis course presents the principles of laser tissue bonding, as well as experimental and clinical applications of this technique in different surgical fields. Thermally induced modifications at the microscopic scale in proteins of the extracellular matrix is described as the basic mechanism of laser-induced tissue bonding. The association of near infrared laser irradiation with organic or nanostructured chromophores applied topically to induce tissue fusion an repair is discussed, showing how lasers hold the promise of providing instantaneous, watertight seals, which is important in many critical surgeries, such as, for example, for vascular repairs, without the introduction of foreign materials, such as sutures or staples. Other advantages over conventional suturing include reduced operation times, fewer skill requirements, decreased foreign-body reaction and therefore reduced inflammatory response, increased ability to induce regeneration of the original tissue architecture, and an improved cosmetic appearance. A particular focus will be given on corneal laser welding in ophthalmic surgery, which is presently the most used clinical applications of this technique in patients. Finally, recent experimental applications employing plasmonic gold nanoparticles as new laser-activated chromophores will be presented and discussed.  

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