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Johannes F. de Boer

Prof. Johannes F. de Boer

Vrije Univ Amsterdam
Dept. of Physics

De Boelelaan 1081


tel: 31 20 5987972
fax: 31 20 5987991
E-mail: jfdeboer@few.vu.nl


Dr. de Boer graduated from the University of Amsterdam, the Netherlands, in 1995, obtaining his Ph.D. in experimental physics. He did a postdoctoral fellowship at the Academic Medical Center, Amsterdam, The Netherlands. In 1997 he moved to the Beckman Laser Institute, University of California at Irvine as an Academic Assistant Researcher and was promoted to Assistant Adjunct Professor, Dept. of Surgery, in 1998. Dr. de Boer joined the Wellman Laboratories of Photomedicine, Harvard Medical School in 2001 as an Assistant Professor and was promoted to Associate Professor, Harvard Medical School, in 2005. In 2008 Dr. de Boer moved back to the Netherlands, taking up a full professor position at the Physics Department, VU University, Amsterdam, and Head of the Imaging Group at the Rotterdam Ophthalmic Institute, Rotterdam. In 2010 he became director of the Institute for Lasers, Life and Biophotonics Amsterdam (LaserLaB Amsterdam). He is currently developing a Biomedical Photonics program at the VU University and the VU medical center, Amsterdam.

Dr. de Boer has over 80 peer reviewed publications, and an H-index of 38. From 2003 until 2007, he served as Topical Editor for biomedical optics for the journal Optics Letters.

Dr. de Boer's interests are primarily focused on the development of new optical diagnostic technologies and the translation of these technologies to clinical applications. Over the past 10 years he has made significant contributions to the field of Optical Coherence Tomography. He has led the development of Polarization Sensitive OCT (PS-OCT). This technology measures the depth resolved changes in the polarization state of light reflected from biological tissues, which allows depth resolved measurement of tissue birefringence. He was the first to measure the depth resolved human Retinal Nerve Fiber Layer (RNFL) birefringence in vivo. It was established that the RNFL birefringence in normal subjects depends on retinal location. He has played an important role in the development of Optical Doppler Tomography (ODT), and the combination of polarization sensitivity with flow sensitivity, allowing simultaneous imaging of blood flow and polarization properties of tissue. He has made major contributions to a technological advance, Spectral Domain OCT, improving the sensitivity of OCT by 100 to 1000 - fold. This sensitivity improvement provides a paradigm shift from point sampling to comprehensive screening of large tissue volumes. After his first demonstration, video rate retinal Spectral Domain OCT imaging has become a commercial instrument widely adopted by the clinical ophthalmic community.

Lecture Title(s)

OCT, Polarization and Dynamic Light Scattering Techniques in Biophotonics

In this course, the principles of Optical Coherence Tomography (OCT) will be taught. Spectral Domain OCT has revolutionized OCT by the more than hundred fold improvement in sensitivity. This has led to real time video rate imaging of human organs such as the eye, coronary artery and esophagus. Contrast enhancement techniques such as polarization sensitivity and Doppler have provided new contrast mechanisms to better identify and quantify tissue structure and function. Spectral Domain OCT technologies provide unparalleled phase sensitivity, permitting the measurements of minute changes inside cells, which provide a signature of transport phenomenon. The course puts OCT as an imaging technology in the broader context of biomedical optics and discusses its role in modern image based medicine.
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