• Explore Membership
  • Student Services
  • Early Career Resources
  • Corporate Membership
  • SPIE Professional Magazine
  • Archives
    Contact SPIE Professional
    Editorial Calendar and Advertising
Print PageEmail Page
SPIE Professional July 2012

aFTLS Analysis for Sickle-Cell Disease

SPIE Professional R&D Highlights

Subra Suresh, director of the National Science Foundation (USA), is a co-author of a recent open-access paper in the Journal of Biomedical Optics on a new optical technique for studying sickle-cell disease.

In “Anisotropic light scattering of individual sickle red blood cells,” an international team of researchers introduce the anisotropic Fourier transform light-scattering (aFTLS) technique to measure and observe biophysical properties in the red blood cells (RBCs) of people with the inherited blood disorder.

They report the results of both static and dynamic light scattering on sickle-shaped RBCs. The technique may play a role in better understanding the pathophysiology of sickle cell disease and could be combined with other optical imaging techniques in the future to study other RBC-related diseases.

  NSF Director Subra Suresh (left) with SPIE President Eustace Dereniak at a meeting of the Council of Scientific Society Presidents in May.

The authors, who include Youngchan Kim, John M. Higgins, Ramachandra R. Dasari, and SPIE member YongKeun Park, report that “the dynamic light-scattering analysis reveals alterations in mechanical properties depending on the morphological type of sickle RBCs.”

The results with the aFTLS technique “provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs,” the authors state.

Suresh, a former dean of the MIT School of Engineering, was an invited speaker at a recent meeting of the Council of Scientific Society Presidents, an organization of past, future, and current presidents of about 60 scientific federations and societies.

Source: Journal of Biomedical Optics 17, 040501 (2012).

Have a question or comment about this article? Write to us at spieprofessional@spie.org.


To receive a print copy of SPIE Professional, the SPIE member magazine, become an SPIE member.

DOI: 10.1117/2.4201207.27

Ready for the benefits of individual SPIE membership?
Join or Renew
Already a member? Get access to member-only content.
Sign In


 American Elements

LaCroix Optical logo

Optimax Systems logo

Photon Engineering logo

logo for Software Spectra

Synopsys logo 

University of Rochester, Institute of Optics

Place your organization name here! Reach a highly qualified audience and build visibility in the optics and photonics community by advertising in SPIE Professional

Like SPIE on Facebook

SPIE Facebook page

The SPIE Facebook page is a great place to find and share news on optics programs and photonics events.