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Conference 12033 > Paper 12033-56
Paper 12033-56

Resampling and harmonization for mitigation of heterogeneity in imaging parameters: a comparative study

In person: 24 February 2022 • 8:00 AM - 8:20 AM PST

Abstract

Recent studies have highlighted the impact of variation in image acquisition protocols on the reproducibility of radiomic features, especially in datasets containing scans from multiple vendors. We assess approaches to mitigate the impact of image acquisition heterogeneity: resampling the images to minimum/maximum voxel spacing parameters, harmonization using nested ComBat (voxel spacing and/or image acquisition parameters as batch effects), and combinations of the resampling and harmonization methods. The features derived from these methods are subject to a novel phenotyping approach based on unsupervised hierarchical clustering that identifies statistically significant radiomic phenotypes. These phenotypes are integrated with PDL1 expression, ECOG status, BMI and smoking status in a multivariate Cox proportional hazards model to predict progression-free survival in 124 stage 4 NSCLC patients treated at our institution with first-line PEMBRO monotherapy or combination chemotherapy.

Presenter

Univ. of Pennsylvania (United States)
Apurva Singh is a PhD student in the Department of Bioengineering at the University of Pennsylvania. She received her BTech in electronics and communication engineering from Manipal Academy of Higher Education, Manipal, India, and her MS degree in electrical and computer engineering from George Washington University, Washington D.C. Her current research interests focus on the development of novel radiogenomic biomarkers to characterize intratumor heterogeneity for improved prognosis in lung cancer patients.
Presenter/Author
Univ. of Pennsylvania (United States)
Author
Hannah Horng
Univ. of Pennsylvania (United States)
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Univ. of Pennsylvania (United States)
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Univ. of Pennsylvania (United States)
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Univ. of Pennsylvania (United States)
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Univ. of Pennsylvania (United States)
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Univ. of Pennsylvania (United States)