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Conference 12032 > Paper 12032-63
Paper 12032-63

Longitudinal changes of connectomes and graph theory measures in aging

21 February 2022 • 6:00 PM - 7:30 PM PST | Golden State Hall

Abstract

Changes in brain structure and connectivity in aging can be probed through diffusion weighted MRI and summarized with structural connectome matrices. Complex network analysis based on graph theory has been applied to provide measures that are correlated with neurobiological variations and can help guide quantitative study of brain function. However, the understanding of how connectomes change longitudinally is limited. In this work, we evaluate modern pipelines to obtain the connectomics data from diffusion weighted MRI scans across different sessions from control subjects (55-99 years old) in the Baltimore Longitudinal Study of Aging and Cambridge Centre for Ageing and Neuroscience. From the connectivity matrices, we compute graph theory measures to understand their brain networks and apply a linear mixed effects model to study their longitudinal changes with respect to age. With this approach, we computed 14 graph theory measures of 1469 healthy subjects (2476 scans) and found statistically significant correlations between all 14 measures and age. In this analysis: 1) the brain becomes more segregated but less integrated in aging; 2) the overall network cost increases for older subjects; 3) the small-world organizations remain stable; and 4) due to high intra-subject variance, there is not clear trend for longitudinal changes of graph theory measures of individual subjects. Therefore, while useful to investigate brain evolution in aging at the population level, improvements in the connectome reconstruction are needed to decrease single subject variability for individual inference.

Presenter

Vanderbilt Univ. (United States), National Institute on Aging, National Institutes of Health (United States)
Yuzhe Wang is a junior at Vanderbilt University, TN, studying computer science and mathematics. During his time at Vanderbilt, he worked in the Medical-image Analysis and Statistical Interpretation Lab under the supervision of Dr. Bennett Landman and Dr. Francois Rheault. His research focuses on human connectomes in aging.
Author
Vanderbilt Univ. (United States)
Author
Vanderbilt Univ. (United States)
Author
Vanderbilt Univ. Medical Ctr. (United States), Vanderbilt Univ. Institute of Imaging Science, Vanderbilt Univ. (United States)
Author
Lori L. Beason-Held
National Institute on Aging, National Institutes of Health (United States)
Author
National Institute on Aging, National Institutes of Health (United States)
Author
Susan M. Resnick
National Institute on Aging, National Institutes of Health (United States)
Presenter/Author
Vanderbilt Univ. (United States), National Institute on Aging, National Institutes of Health (United States)