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Conference 12033 > Paper 12033-34
Paper 12033-34

Effects of feature type and multiple scanners on brain metastasis stereotactic radiosurgery outcome prediction

In person: 23 February 2022 • 8:00 AM - 8:20 AM PST

Abstract

The prediction of brain metastasis (BM) response to stereotactic radiosurgery could assist clinicians when choosing BM treatments. Pre-treatment clinical and magnetic resonance imaging (MRI) radiomic features were used with a random forest classifier and bootstrap experimental design to investigate predicting treatment endpoints. It was found that in-field progression, out-of-field progression, and 1-year overall survival could be predicted with respective AUC estimates of 0.70, 0.57 and 0.66. The effect of incorporating data from multiple MR scanners was also investigated. MR scanner variability was found to decrease classifier AUC, though pre-processing methods were found to counteract this effect for some scanner models.

Presenter

Gerald C. Baines Ctr. for Translational Cancer Research (Canada), Western Univ. (Canada)
David DeVries is completing his PhD in the Department of Medical Biophysics in Ontario, Canada under the supervision of Dr. Aaron Ward and Dr. George Hajdok at the London Regional Cancer Program. David has previously completed a MSc in physics at Queen’s University and the Cancer Centre of Southeastern Ontario, and a joint physics and computer science undergraduate at the University of Waterloo. David’s current research focuses specifically on brain cancers and how statistical and machine learning approaches can be used to gain insight into how these cancers respond to treatment. After completing his PhD, David plans to pursue a career as a clinical medical physicist.
Presenter/Author
Gerald C. Baines Ctr. for Translational Cancer Research (Canada), Western Univ. (Canada)
Author
Frank Lagerwaard
Amsterdam UMC (Netherlands)
Author
Haaglanden Medical Ctr. (Netherlands), Holland Proton Therapy Ctr. (Netherlands)
Author
Timothy Yeung
RefleXion Medical (United States)
Author
George Rodrigues
Western Univ. (Canada)
Author
Western Univ. (Canada)
Author
Gerald C. Baines Ctr. for Translational Cancer Research (Canada), Western Univ. (Canada)