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Proceedings Paper

In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation variations with photoacoustic microscopy
Author(s): Zhongjiang Chen; Sihua Yang; Da Xing
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Paper Abstract

A method for noninvasive simultaneously detecting hemoglobin oxygen saturation (SO2) and carboxyhemoglobin saturation (SCO) in subcutaneous microvasculature with multi-wavelength photoacoustic microscopy (PAM) is presented. In vitro blood samples mixed with different concentration of carboxyhemoglobin were used to testify the feasibility and accuracy of the PAM. Moreover, fixed-point detection of SO2 and SCO of the vessel in mouse ear were obtained. And the changes of SO2 and SCO from normoxia to carbon monoxia hypoxia were dynamically recorded in vivo. Experimental results demonstrate that the PAM has the capability to detect SO2 and SCO, which has potential application in clinic.

Paper Details

Date Published: 11 December 2012
PDF: 13 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532U (11 December 2012); doi: 10.1117/12.999746
Show Author Affiliations
Zhongjiang Chen, South China Normal Univ. (China)
Sihua Yang, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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