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Proceedings Paper

In vivo integrated photoacoustic ophthalmoscopy, optical coherence tomography, and scanning laser ophthalmoscopy for retinal imaging
Author(s): Wei Song; Rui Zhang; Hao F. Zhang; Qing Wei; Wenwu Cao
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Paper Abstract

The physiological and pathological properties of retina are closely associated with various optical contrasts. Hence, integrating different ophthalmic imaging technologies is more beneficial in both fundamental investigation and clinical diagnosis of several blinding diseases. Recently, photoacoustic ophthalmoscopy (PAOM) was developed for in vivo retinal imaging in small animals, which demonstrated the capability of imaging retinal vascular networks and retinal pigment epithelium (RPE) at high sensitivity. We combined PAOM with traditional imaging modalities, such as fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), and auto-fluorescence scanning laser ophthalmoscopy (AF-SLO), for imaging rats and mice. The multimodal imaging system provided more comprehensive evaluation of the retina based on the complementary imaging contrast mechanisms. The high-quality retinal images show that the integrated ophthalmic imaging system has great potential in the investigation of blinding disorders.

Paper Details

Date Published: 11 December 2012
PDF: 7 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85530V (11 December 2012); doi: 10.1117/12.999544
Show Author Affiliations
Wei Song, Harbin Institute of Technology (China)
Northwestern Univ. (United States)
Rui Zhang, Harbin Institute of Technology (China)
Hao F. Zhang, Northwestern Univ. (United States)
Qing Wei, Northwestern Univ. (United States)
Wenwu Cao, Harbin Institute of Technology (China)
The Pennsylvania State Univ. (United States)

Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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