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Proceedings Paper

Size control of ferrimagnetic iron oxide nanocubes to achieve optimum static dephasing regime r[sub]2[/sub] relaxivity for in vivo MRI
Author(s): Youjin Lee; Nohyun Lee; Mihyun Park; Seung Hong Choi; Taeghwan Hyeon
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Paper Abstract

Ferrimagnetic nanoparticles have been limited in in vivo application because nanoparticles aggregate due to its remanent magnetization. Uniform-sized ferromagnetic iron oxide nanocubes with similar value of bulk saturated magnetization were synthesized. Control of nanocubes’ size minimized their remanence. PEG-phospholipid encapsulation enabled spacing to prevent the aggregation. As a result, water-dispersed single core ferrimagnetic iron oxide nanocubes were successfully prepared and their r2 relaxivity was 761 s-1mM-1. It was very close to theoretical calculated value 800 s-1mM-1 in static dephasing regime. in vivo MR images were obtained after intravenous injection of 22 nm nanoparticles to a mouse. The MR signal of tumor site changed significantly. In this research, synthesized ferrimagnetic iron oxide nanocubes showed a superior T2 contrast effect and it would be able to improve the quality of early diagnosis and detection of tumor.

Paper Details

Date Published: 24 October 2012
PDF: 6 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482X (24 October 2012); doi: 10.1117/12.999330
Show Author Affiliations
Youjin Lee, Seoul National Univ. (Korea, Republic of)
Nohyun Lee, Seoul National Univ. (Korea, Republic of)
Mihyun Park, Seoul National Univ. (Korea, Republic of)
Seung Hong Choi, Seoul National Univ. Hospital (Korea, Republic of)
Seoul Medical Research Ctr. (Korea, Republic of)
Taeghwan Hyeon, Seoul National Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee M.D.; Vijay K. Varadan, Editor(s)

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