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Proceedings Paper

Detection of atherosclerotic vascular tissue from optical coherence tomography images
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Paper Abstract

Atherosclerotic coronary artery disease continues to be one of the major causes of mortality. Prevention, diagnosis and treatment of atherosclerotic coronary artery disease are dependent on the detection of high risk atherosclerotic plaque. As age is one of the most important risk factors, atherosclerosis worsens steadily with increasing age. Automatic characterization of atherosclerotic plaque using the optical coherence tomography (OCT) images provides a powerful tool to classify patients with high risk plaque. In this study we develop an automatic classifier to detect atherosclerotic plaque in young and old Watanabe heritable hyperlipidemic (WHHL) rabbits, using OCT images without reliance on visual inspection. Our classifier based on texture analysis technique may provide an efficient tool for detecting invisible changes in tissue structure. We extracted a set of 22 statistical textural features for each image using the spatial gray level dependence matrix (SGLDM) method. An optimal scalar feature selection process was carried to select the best discriminating features that employ the Fisher discriminant ratio (FDR) criterion, and cross correlation measure between the pairs of features. Using these optimal features, we formed a combination of 5 best classification features using an exhaustive search method. A combined feature set was finally employed for the classification of plaque. We obtained correct classification rate and validation of 76.67% and 75% respectively.

Paper Details

Date Published: 24 October 2012
PDF: 7 pages
Proc. SPIE 8412, Photonics North 2012, 841204 (24 October 2012); doi: 10.1117/12.981916
Show Author Affiliations
Ammu Prakash, Univ. of Manitoba (Canada)
Mark Hewko, National Research Council Canada (Canada)
Mike Sowa, National Research Council Canada (Canada)
Sherif Sherif, Univ. of Manitoba (Canada)

Published in SPIE Proceedings Vol. 8412:
Photonics North 2012
Jean-Claude Kieffer, Editor(s)

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