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Proceedings Paper

Immune Response Following Photodynamic Therapy For Bladder Cancer
Author(s): Unyime O. Nseyo; Raymond K. Whalen; Matthew R. Duncan; Brian Berman; Scott Lundahl
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Paper Abstract

This study was undertaken to determine if photodynamic therapy (PDT) produces an immunologic response in patients treated for bladder cancer. Gamma interferon, interleukin 1-beta, interleukin 2 and tumor necrosis factor-alpha were assayed in the urine of four patients treated with photodynamic therapy for bladder cancer, in seven patients undergoing transurethral procedures, and in five healthy control subjects. Quantifiable concentrations of all cytokines, except gamma interferon, were measured in urine samples from the PDT patients treated with the highest light energies, while no urinary cytokines were found in the PDT patient who received the lowest light energy or in the control subjects. These findings suggest that a local immunologic response may occur following PDT for bladder cancer. Such an immunologic response activated by PDT may be an additional mechanism involved in bladder tumor destruction.

Paper Details

Date Published: 13 June 1989
PDF: 7 pages
Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); doi: 10.1117/12.978005
Show Author Affiliations
Unyime O. Nseyo, University of California (United States)
Raymond K. Whalen, University of California (United States)
Matthew R. Duncan, California and Veterans Administration Medical Center (United States)
Brian Berman, California and Veterans Administration Medical Center (United States)
Scott Lundahl, University of California (United States)

Published in SPIE Proceedings Vol. 1065:
Photodynamic Therapy: Mechanisms
Thomas J. Dougherty, Editor(s)

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