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Proceedings Paper

The Role Of FT-IR In The Identification Of Domoic Acid, A New Shellfish Toxin
Author(s): Michael Falk
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Paper Abstract

A brief but serious outbreak of poisoning by mussels occurred in Canada in December 1987. In a round-the-clock effort, the toxin that caused this outbreak was isolated in our laboratory and identified as domoic acid, a naturally-occurring substance that had not previously been reported to cause human poisoning. The identification of the toxin was achieved by the concerted use of spectroscopic methods, among them micro-FT-IR spectroscopy. The use of the FT-IR microscope allowed high-quality infrared spectra to be obtained on sub-microgram quantities of the early isolates of the toxin. The microscopic method had an additional advantage in that it enabled us to carry out a rough but rapid separation of the compound of interest from admixtures of unrelated substances by recording the spectra of a gradually dried out drop of solution on a microscope plate. Following the positive identification of the toxin as domoic acid, a detailed spectroscopic study was made of this important molecule in its several isomeric forms.

Paper Details

Date Published: 1 December 1989
PDF: 1 pages
Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); doi: 10.1117/12.969641
Show Author Affiliations
Michael Falk, National Research Council (Canada)

Published in SPIE Proceedings Vol. 1145:
7th Intl Conf on Fourier Transform Spectroscopy
David G. Cameron, Editor(s)

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