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Proceedings Paper

Dehydration Of Erythromycin Dihydrate A Microscopy-FTIR Application
Author(s): M. A. Smith; R. S. Chao; M. S. Bergren; D. A. Clark
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Paper Abstract

A novel application of microscopy-FTIR to monitor the dehydration of some hydrate compounds has been established, and some major instrumental parameters are identified. An application to erythromycin dihydrate indicated that the most notable spectral changes before and after dehydration are observed in the carbonyl region, particularly the lactone carbonyl band. Spectral comparison with conventional FTIR preparations, such as Nujol and KBR methods, are pre-sented to demonstrate the dehydration mechanism of erythromycin dihydrate. Also presented are the differential scanning calorimetry (DSC) and hot stage microscope (HSM) data to support the hypothesis that the FTIR-microscope accessory induces a transformation of erythromycin dihydrate into a metastable anhydrate form which will rehydrate rapidly when water vapor is present. With further thermal treatment the metastable form would convert to a stable anhydrate form via an amorphous form.

Paper Details

Date Published: 1 December 1989
PDF: 1 pages
Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); doi: 10.1117/12.969625
Show Author Affiliations
M. A. Smith, The Upjohn Company (United States)
R. S. Chao, The Upjohn Company (United States)
M. S. Bergren, The Upjohn Company (United States)
D. A. Clark, The Upjohn Company (United States)

Published in SPIE Proceedings Vol. 1145:
7th Intl Conf on Fourier Transform Spectroscopy
David G. Cameron, Editor(s)

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