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Proceedings Paper

Direct Determination Of Conformational Disorder In Biological Membranes By FT-IR Spectroscopy
Author(s): Richard Mendelsohn; Mark Davies; Herbert F. Schuster; Joseph W. Brauner; Richard A. Dluhy
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Paper Abstract

Although the determination of conformational disorder in biological membranes is an important goal of current membrane biophysics, a quantitative formulation has remained elusive. The current study describes a successful determination of trans-gauche isomerization at specific depths in phospholipid bilayers. The approach was suggested by Snyder and Poore (1) and utilizes the CD2 rocking modes of specifically deuterated hydrocarbons as conformational probes. This CD2 probe frequency is dependent on the conformation of the C-C-C skeleton of which the central carbon atom contains the CD2 moiety. The various conformations give rise to discrete (but weak) bands in the IR, as summarized below:

Paper Details

Date Published: 1 December 1989
PDF: 2 pages
Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); doi: 10.1117/12.969621
Show Author Affiliations
Richard Mendelsohn, Rutgers University (United States)
Mark Davies, Rutgers University (United States)
Herbert F. Schuster, Rutgers University (United States)
Joseph W. Brauner, Rutgers University (United States)
Richard A. Dluhy, Batelle Memorial Institute (United States)

Published in SPIE Proceedings Vol. 1145:
7th Intl Conf on Fourier Transform Spectroscopy
David G. Cameron, Editor(s)

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