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Proceedings Paper

A Fiberoptic Antibody-Based Biosensor With Time-Resolved Detection
Author(s): T. Vo-Dinh; T. Nolan; Y. F. Cheng; J. P. Alarie; M. J. Sepaniak
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Paper Abstract

A phase-resolved fiberoptic antibody-based biosensor is desci ibed, which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiberoptic sensors, and the selectivity of phase-resolved detection. The device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. The limit of detection of benzo(a)pyrene tetrol is in the attomole range (10-18 moles).

Paper Details

Date Published: 13 February 1990
PDF: 7 pages
Proc. SPIE 1172, Chemical, Biochemical, and Environmental Fiber Sensors, (13 February 1990); doi: 10.1117/12.963196
Show Author Affiliations
T. Vo-Dinh, Oak Ridge National Laboratory (United States)
T. Nolan, Oak Ridge National Laboratory (United States)
Y. F. Cheng, Oak Ridge National Laboratory (United States)
J. P. Alarie, University of Tennessee (United States)
M. J. Sepaniak, University of Tennessee (United States)


Published in SPIE Proceedings Vol. 1172:
Chemical, Biochemical, and Environmental Fiber Sensors
Robert A. Lieberman; Marek T. Wlodarczyk, Editor(s)

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