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Proceedings Paper

Cellular And Preclinical Examination Of Photodynamic Therapy
Author(s): Charles J. Gomer; Angela Ferrario; Natalie Rucker; Sam Wong; Elisa Morinelli; Grace Liu; Bernard C. Szirth
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Paper Abstract

In-vitro studies have been performed to compare the mode of action of porphyrin induced photodynamic therapy and hyperthermia. Parent and temperature resistant clones of Chinese hamster and mouse fibrosarcoma cells were treated with either PDT or hyperthermia. Quantitative survival curves obtained from these experiments indicate that temperature resistant cells are not cross resistant to PDT even though both treatments induce the synthesis of stress proteins. In-vivo studies were performed to evaluate the photosensitizing efficiency to mono-l-aspartyl chlorin e 6 (NPe6). Tumor response and normal skin response were determined using a murine tumor system. The studies indicate that NPe6 is an extremely effective tumor photosensitizer with rapid in-vivo clearance properties which may eliminate the side effects of prolonged and systemic skin photosensitivity.

Paper Details

Date Published: 17 March 1989
PDF: 4 pages
Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); doi: 10.1117/12.960178
Show Author Affiliations
Charles J. Gomer, USC School of Medicine (United States)
Angela Ferrario, USC School of Medicine (United States)
Natalie Rucker, USC School of Medicine (United States)
Sam Wong, USC School of Medicine (United States)
Elisa Morinelli, USC School of Medicine (United States)
Grace Liu, USC School of Medicine (United States)
Bernard C. Szirth, USC School of Medicine (United States)

Published in SPIE Proceedings Vol. 0997:
Advances in Photochemotherapy
Tayyaba Hasan, Editor(s)

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