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Proceedings Paper

Interstitial Hyperthermia Treatment Using Nd:YAG Laser
Author(s): Masoud Panjehpour; Andrew J Milligan; Bergein F Overholt
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Paper Abstract

Treatment of tumors with hyperthermia with other agents can be effective under certain circumstances. However, often it is impossible to adequately treat tumors because of the difficulties in delivering uniform thermal doses throughout the entire tumor volume. This difficulty may be caused by many different factors including perfusion differences between tumor and normal tissue and differences in thermal properties between these tissues. With interstitial techniques however, some of these difficulties can be overcome. We have developed an interstitial laser system for delivery of heat to tissue. The system utilizes the output of an Nd:YAG laser directed into a fiberoptic probe which can be inserted into a tumor. Sapphire contact tips are used to deliver laser energy into the tissue. A series of animals were heated with a single probe. Temperature measured by small implanted thermocouples was controlled via a feedback circuit to a constant value over this interval. The control system was able to maintain temperature to within 0.3°C. This pilot study showed that this technique was suitable for interstitial hyperthermia. Continued work into the characterization of thermal profiles in tissue resulting from laser treatment must be performed. Ultimately, light from the interstitial probes will be used in combination with specific photosensitizers for delivery of photodynamic therapy in conjunction with hyperthermia.

Paper Details

Date Published: 8 August 1989
PDF: 6 pages
Proc. SPIE 1064, Thermal and Optical Interactions with Biological and Related Composite Materials, (8 August 1989); doi: 10.1117/12.951956
Show Author Affiliations
Masoud Panjehpour, Thompson Cancer Survival Center (United States)
Andrew J Milligan, Thompson Cancer Survival Center (United States)
Bergein F Overholt, The University of Tennessee (United States)

Published in SPIE Proceedings Vol. 1064:
Thermal and Optical Interactions with Biological and Related Composite Materials
Michael J. Berry; George M. Harpole, Editor(s)

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