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Proceedings Paper

Synthesis of iron oxide nanotubes and their applications in neuroscience and drug delivery
Author(s): Linfeng Chen; Jining Xie; Kiran R. Aatre; Justin Yancey; Malathi Srivatsan; Vijay K. Varadan
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Paper Abstract

This paper reports the synthesis of three types of iron oxide nanotubes, including hematite (α-Fe2O3), maghemite (γ-Fe2O3) and magnetite (Fe3O4), and their applications in neuroscience and drug delivery. Two methods, template-assisted thermal decomposition method and hydrothermal method, were used for synthesizing hematite nanotubes, and maghemite nanotubes were obtained from hematite nanotubes by thermal treatment. Template-assisted filtering method was used for synthesizing magnetite nanotubes from ferrofluid. The crystalline, morphology and magnetic properties of the synthesized iron oxide nanotubes were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and vibrating sample magnetometer (VSM), respectively. The biocompatibility of the synthesized hematite nanotubes was confirmed by the survival and differentiation of PC12 cells in the presence of the hematite nanotubes coupled to nerve growth factor (NGF). The capacity of hematite nanotubes for coupling and leasing NGF was confirmed by cultivating PC12 cells in the presence of NGF-loaded hematite nanotubes. The drug loading and release capabilities of hematite nanotubes were tested by using ibuprofen sodium salt (ISS) as a drug model. Based on the experimental results presented in this paper, it can be concluded that iron oxide nanotubes have good biocompatibility with neurons, could be used in guding neurite growth, and are promising candidates for drug delivery.

Paper Details

Date Published: 24 October 2012
PDF: 8 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854867 (24 October 2012); doi: 10.1117/12.946051
Show Author Affiliations
Linfeng Chen, Univ. of Arkansas (United States)
Jining Xie, Univ. of Arkansas (United States)
Kiran R. Aatre, Univ. of Arkansas (United States)
Justin Yancey, Arkansas State Univ. (United States)
Malathi Srivatsan, Arkansas State Univ. (United States)
Vijay K. Varadan, Univ. of Arkansas (United States)

Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee M.D.; Vijay K. Varadan, Editor(s)

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