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Proceedings Paper

Optical Transduction Of Chemoreceptive Events: Towards A Fiber-Optic Biosensor
Author(s): Ulrich J. Krull; R. Stephen Brown; A. Safarzadeh-Amiri
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Paper Abstract

Phosphatidyl choline-cholesterol and stearic acid monolayers and multilayers were deposited onto borosilicate glass, quartz and crystalline silicon surfaces by transfer from the air-water interface of a Langmuir-Blodgett trough. Contact angle, ellipsometric, X-ray photoelectron and fluorescence measurements provided characterization of phospholipid monolayers on hydrated or alkylated silicate surfaces. A fluorescent lipid film supported on a quartz optical fiber demonstrated the feasibility of preparation of an evanescent-wave based intrinsic optrode. Further development of intrinsic biosensors based on lipid membrane structures is described in terms of optical conduction of lipid multilayer wave guides, and new membrane-soluble fluorescence probes such as trans-4-dimethylamino-4'-(1-oxobutyl)stilbene.

Paper Details

Date Published: 21 June 1988
PDF: 8 pages
Proc. SPIE 0906, Optical Fibers in Medicine III, (21 June 1988); doi: 10.1117/12.945254
Show Author Affiliations
Ulrich J. Krull, University of Toronto (Canada)
R. Stephen Brown, University of Toronto (Canada)
A. Safarzadeh-Amiri, University of Toronto (Canada)

Published in SPIE Proceedings Vol. 0906:
Optical Fibers in Medicine III
Abraham Katzir, Editor(s)

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